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Dronedarone

Name: Dronedarone
Brand: Selleck Chemicals
SKU: S5787
Rating: 5 (1 reviews)

Synonyms: SR33589

Catalog No.S5787 Purity: 99.88%

Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).

Dronedarone Chemical Structure

CAS: 141626-36-0

Selleck's Dronedarone has been cited by 1 publication

Purity & Quality Control

Batch: S578701 Purity: 99.88%

99.88

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Biological Activity

Description	Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01430806	Unknown status	ICD\|ICD SHOCKS\|DRONEDARONE	Rabin Medical Center	October 2011	Not Applicable
NCT01266681	Unknown status	Atrial Fibrillation	Eastbourne General Hospital	March 2011	Not Applicable
NCT01199081	Completed	Atrial Fibrillation	Sanofi	October 2010	Phase 4
NCT01213368	Completed	Atrial Fibrillation	Sanofi	September 2010	Phase 2
NCT01140581	Completed	Atrial Fibrillation	Sanofi	September 2010	Phase 4
NCT01070667	Unknown status	Paroxysmal Atrial Fibrillation	Eastbourne General Hospital	March 2010	Phase 4

Chemical lnformation & Solubility

Molecular Weight	556.76	Formula	C₃₁H₄₄N₂O₅S
CAS No.	141626-36-0	SDF	--
Density	1.143 g/mL
Smiles	CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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