Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Estradiol Benzoate For research use only.

Estradiol Benzoate

Synonyms: β-Estradiol 3-benzoate

Estradiol benzoate(β-Estradiol 3-benzoate) is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

Estradiol Benzoate Chemical Structure

Estradiol Benzoate Chemical Structure

CAS: 50-50-0

Selleck's Estradiol Benzoate has been cited by 3 publications

Purity & Quality Control

Batch: S411001 DMSO] 19 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.92%
99.92

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Biological Activity

Description Estradiol benzoate(β-Estradiol 3-benzoate) is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
Targets
mERα [1] hERα [1]
2.3 nM 28 nM
In vitro
In vitro

Estradiol benzoate is asynthetic ester, specifically the 3-benzoyl ester, of the natural estrogen, estradiol. Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock. This compound binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol. [1]

Chemical lnformation & Solubility

Molecular Weight 376.49 Formula

C25H28O3
CAS No. 50-50-0 SDF Download Estradiol Benzoate SDF
Smiles CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 19 mg/mL ( (50.46 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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