Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Estradiol Cypionate For research use only.

Estradiol Cypionate

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Estradiol Cypionate Chemical Structure

Estradiol Cypionate Chemical Structure

CAS: 313-06-4

Selleck's Estradiol Cypionate has been cited by 2 publications

Purity & Quality Control

Batch: S404601 DMSO] 79 mg/mL] false] Ethanol] 55 mg/mL] false] Water] Insoluble] false Purity: 99.88%
99.88

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Biological Activity

Description Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
Targets
ER [1]
In vitro
In vitro Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively.[1] Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03443089 Completed Contraception Galeno Desenvolvimento de Pesquisas Clínicas|Biolab Sanus Farmaceutica March 31 2017 Phase 1

Chemical lnformation & Solubility

Molecular Weight 396.56 Formula

C26H36O3
CAS No. 313-06-4 SDF Download Estradiol Cypionate SDF
Smiles CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (199.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 55 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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