Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Ethynodiol diacetate For research use only.

Ethynodiol diacetate

Synonyms: 8080 CB,Ethynodiol acetate

Ethynodiol diacetate (8080 CB,Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills.

Ethynodiol diacetate Chemical Structure

Ethynodiol diacetate Chemical Structure

CAS: 297-76-7

Purity & Quality Control

Batch: S316001 DMSO] 77 mg/mL] false] Water] 77 mg/mL] false] Ethanol] Insoluble] false Purity: 99.22%
99.22

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Biological Activity

Description Ethynodiol diacetate (8080 CB,Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills.
Targets
Progesterone receptor [1]
In vitro
In vitro

Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. [1] Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte. [2]
In Vivo
In vivo

Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). [3] Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys. [4]

Chemical lnformation & Solubility

Molecular Weight 384.51 Formula

C24H32O4
CAS No. 297-76-7 SDF Download Ethynodiol diacetate SDF
Smiles CC(=O)OC1CCC2C3CCC4(C(C3CCC2=C1)CCC4(C#C)OC(=O)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 77 mg/mL ( (200.25 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 77 mg/mL

Ethanol : Insoluble


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In vivo
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