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Metoclopramide HCl

Synonyms: Metoclopramide hydrochloride

Catalog No.S4289 Purity: 99.72%

Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

Metoclopramide HCl Chemical Structure

CAS: 7232-21-5

Selleck's Metoclopramide HCl has been cited by 3 publications

Purity & Quality Control

Batch: S428901 DMSO] 67 mg/mL] false] Water] 67 mg/mL] false] Ethanol] 67 mg/mL] false Purity: 99.72%

99.72

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Biological Activity

Description

Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

Targets

D2 receptor ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05759481	Not yet recruiting	Post-operative Nausea and Vomiting	Milton S. Hershey Medical Center	January 2024	Phase 2
NCT05832151	Recruiting	Diabetic Gastroparesis	CinDome Pharma Inc.	March 27 2023	Phase 2
NCT05008926	Recruiting	Brain Injuries	University Hospital Brest	March 15 2022	Phase 3
NCT04748133	Unknown status	Treatment Complication	Zagazig University	February 20 2021	Not Applicable
NCT02466984	Completed	Nausea\|Vomiting	University Hospital Bordeaux	July 2016	Phase 3

Chemical lnformation & Solubility

Molecular Weight	336.26	Formula	C₁₄H₂₃Cl₂N₃O₂
CAS No.	7232-21-5	SDF	Download Metoclopramide HCl SDF
Smiles	CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 67 mg/mL ( (199.25 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 67 mg/mL

Ethanol : 67 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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