Home Neuronal Signaling Dopamine Receptor antagonist - 5-HT Receptor modulator Metoclopramide hydrochloride hydrate For research use only.

Metoclopramide hydrochloride hydrate

Synonyms: Clorpa, Gimoti, Maxolon, Reglan

Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.

Metoclopramide hydrochloride hydrate Chemical Structure

Metoclopramide hydrochloride hydrate Chemical Structure

CAS: 54143-57-6

Selleck's Metoclopramide hydrochloride hydrate has been cited by 2 publications

Purity & Quality Control

Batch: S594901 DMSO] 71 mg/mL] false] Water] 71 mg/mL] false] Ethanol] 71 mg/mL] false Purity: 99.96%
99.96

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Biological Activity

Description Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.
Targets
Dopamine receptor [1] 5HT3 receptor [1] 5HT4 receptor [1]
In Vivo
In vivo

Metoclopramide attenuates MSG-induced lying-on-belly behaviours of rats.[2]
Animal Research Animal Models Male and Female Sprague Dawley rats
Dosages 5 mg/ml
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Not yet recruiting Post-operative Nausea and Vomiting Milton S. Hershey Medical Center January 2024 Phase 2
NCT05832151 Recruiting Diabetic Gastroparesis CinDome Pharma Inc. March 27 2023 Phase 2
NCT05008926 Recruiting Brain Injuries University Hospital Brest March 15 2022 Phase 3
NCT04748133 Unknown status Treatment Complication Zagazig University February 20 2021 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 354.27 Formula

C14H25Cl2N3O3
CAS No. 54143-57-6 SDF --
Smiles O.Cl.CCN(CC)CCNC(=O)C1=CC(=C(N)C=C1OC)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (200.41 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 71 mg/mL

Ethanol : 71 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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