Home Neuronal Signaling Adrenergic Receptor antagonist Metoprolol Tartrate For research use only.

Metoprolol Tartrate

Synonyms: CGP 2175E

Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.

Metoprolol Tartrate Chemical Structure

Metoprolol Tartrate Chemical Structure

CAS: 56392-17-7

Purity & Quality Control

Batch: Purity: 99.91%
99.91

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Biological Activity

Description Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.
Targets
β-adrenergic receptor [1]
In vitro
In vitro Metoprolol, attenuates cardiomyocyte apoptosis in left ventricular (LV) myocardium of dogs with heart failure (HF). Metoprolol induces the expression of Bcl-2 independent of heart failure (HF) and that this independently confers protection. [1]
In Vivo
In vivo Metoprolol partly reverses the depressed left ventricular (LV) systolic pressure, positive and negative rates of changes in pressure development, ejection fraction, fractional shortening and cardiac output, as well as increased LV end-diastolic pressure in 20 weeks myocardial infarction (MI) rats. Metoprolol partially reverses the elevated levels of plasma norepinephrine and dopamine without affecting the elevated levels of epinephrine. [2] Metoprolol treatment attenuates the development of cardiac dysfunction in streptozotocin (STZ)-diabetic rats. Metoprolol leads to reduced rates of palmitate oxidation, stimulation of glucose oxidation, and increases tissue ATP levels. Metoprolol leads to decreased maximum activity and decreased sensitivity of carnitine palmitoyltransferase I to malonyl-CoA. Metoprolol also increases sarco(endo) plasmic reticulum Ca(2+)-ATPase expression and prevents the reexpression of atrial natriuretic peptide in diabetic hearts of in streptozotocin (STZ)-diabetic rats. [3] Metoprolol, attenuates the increase in collagen content in noninfarcted regions and prevents the increase in right ventricular weight/body weight, and its effect is similar to captopril in rat model with myocardial infarction (MI). Metoprolol treatment tends to increase right ventricular weight and heart weight. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06004453 Recruiting Heart Failure Novartis Pharmaceuticals|Novartis April 5 2023 --
NCT05368831 Not yet recruiting Healthy Volunteers NorthSea Therapeutics B.V. July 2022 Phase 1
NCT05171985 Unknown status COVID-19 Pneumonia|Atrial Fibrillation Tanta University January 2022 Not Applicable
NCT04842981 Terminated Arthritis Rheumatoid|Interaction University of Southern Denmark|Odense University Hospital|Hospital of South West Jutland|King Christian X´Hospital for Rheumatic Diseases|Sygehus Lillebaelt|Odense Patient Data Explorative Network May 25 2021 Phase 1|Phase 2
NCT04840641 Completed Healthy Volunteers|Drug Drug Interaction University of Southern Denmark|SignaTope GmbH Germany March 25 2021 Phase 1

Chemical lnformation & Solubility

Molecular Weight 684.81 Formula

2C15H25NO3.C4H6O6
CAS No. 56392-17-7 SDF Download Metoprolol Tartrate SDF
Smiles CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (146.02 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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