Home Neuronal Signaling Adrenergic Receptor antagonist Metoprolol For research use only.

Metoprolol

Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.

Metoprolol Chemical Structure

Metoprolol Chemical Structure

CAS: 51384-51-1

Selleck's Metoprolol has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
Targets
β1-adrenergic receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06004453 Recruiting Heart Failure Novartis Pharmaceuticals|Novartis April 5 2023 --
NCT05368831 Not yet recruiting Healthy Volunteers NorthSea Therapeutics B.V. July 2022 Phase 1
NCT05171985 Unknown status COVID-19 Pneumonia|Atrial Fibrillation Tanta University January 2022 Not Applicable
NCT04842981 Terminated Arthritis Rheumatoid|Interaction University of Southern Denmark|Odense University Hospital|Hospital of South West Jutland|King Christian X´Hospital for Rheumatic Diseases|Sygehus Lillebaelt|Odense Patient Data Explorative Network May 25 2021 Phase 1|Phase 2
NCT04840641 Completed Healthy Volunteers|Drug Drug Interaction University of Southern Denmark|SignaTope GmbH Germany March 25 2021 Phase 1

Chemical lnformation & Solubility

Molecular Weight 267.36 Formula

C15H25NO3
CAS No. 51384-51-1 SDF --
Smiles CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 53 mg/mL ( (198.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 53 mg/mL

Ethanol : 53 mg/mL


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In vivo
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