Home Neuronal Signaling Adrenergic Receptor inhibitor Nebivolol For research use only.

Nebivolol

Synonyms: Bystolic,R 065824

Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

Nebivolol Chemical Structure

Nebivolol Chemical Structure

CAS: 118457-14-0

Selleck's Nebivolol has been cited by 3 publications

Purity & Quality Control

Batch: S573901 DMSO] 88 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06004453 Recruiting Heart Failure Novartis Pharmaceuticals|Novartis April 5 2023 --
NCT04888728 Completed Idiopathic Pulmonary Fibrosis Daewoong Pharmaceutical Co. LTD. June 30 2021 Phase 1
NCT03847350 Completed Essential Hypertension A.Menarini Asia-Pacific Holdings Pte Ltd July 1 2015 --
NCT01885988 Unknown status Erectile Dysfunction Martin M. Miner MD|Forest Laboratories|The Miriam Hospital March 2013 Phase 4
NCT01057251 Completed Hypertension Forest Laboratories March 2010 Phase 4

Chemical lnformation & Solubility

Molecular Weight 405.43 Formula

C22H25F2NO4
CAS No. 118457-14-0 SDF --
Smiles C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 88 mg/mL ( (217.05 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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