Home Microbiology Bacterial chemical - Antibiotics chemical Nitrofurantoin For research use only.

Nitrofurantoin

Synonyms: Macrodantin, Furadantine, Furadonine

Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.

Nitrofurantoin Chemical Structure

Nitrofurantoin Chemical Structure

CAS: 67-20-9

Selleck's Nitrofurantoin has been cited by 1 publication

Purity & Quality Control

Batch: S453601 DMSO] 47 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

Related compound libraries

Choose Selective Bacterial Inhibitors

Biological Activity

Description Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
In vitro
In vitro Nitrofurantoin is very effective against both outdoor and indoor urinary isolates and can be used empirically for uncomplicated urinary tract infections[3]. Nitrofurantoin can directly injure lung parenchymal cells, probably through oxidant mechanisms[2].
Cell Research Cell lines HeLa cell
Concentrations 5, 10, 20, 40 μM
Incubation Time 24 h
Method HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37˚C and measuring the absorbance at 490 nm in a microplate reader.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05630833 Recruiting Urinary Tract Infections GlaxoSmithKline January 11 2023 Phase 3
NCT05817253 Completed Clinical Audit|Quality Improvement University of British Columbia|Ministry of Health British Columbia September 23 2021 Not Applicable
NCT04900571 Completed Pain Postoperative|Irreversible Pulpitis Altamash Institute of Dental Medicine January 1 2021 Phase 4
NCT02727322 Completed Pelvic Organ Prolapse Halina M Zyczynski MD|University of Pittsburgh August 2016 Phase 4
NCT00678041 Terminated Urinary Tract Infections University of Pittsburgh May 2008 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 238.16 Formula

C8H6N4O5
CAS No. 67-20-9 SDF Download Nitrofurantoin SDF
Smiles C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 47 mg/mL ( (197.34 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Nitrofurantoin | Nitrofurantoin ic50 | Nitrofurantoin price | Nitrofurantoin cost | Nitrofurantoin solubility dmso | Nitrofurantoin purchase | Nitrofurantoin manufacturer | Nitrofurantoin research buy | Nitrofurantoin order | Nitrofurantoin mouse | Nitrofurantoin chemical structure | Nitrofurantoin mw | Nitrofurantoin molecular weight | Nitrofurantoin datasheet | Nitrofurantoin supplier | Nitrofurantoin in vitro | Nitrofurantoin cell line | Nitrofurantoin concentration | Nitrofurantoin nmr