Home Endocrinology & Hormones Adrenergic Receptor agonist Olodaterol For research use only.

Olodaterol

Synonyms: BI 1744

Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).

Olodaterol Chemical Structure

Olodaterol Chemical Structure

CAS: 868049-49-4

Purity & Quality Control

Batch: S448501 DMSO] 77 mg/mL] false] Ethanol] 40 mg/mL] false] Water] Insoluble] false Purity: 99.44%
99.44

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Biological Activity

Description Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).
Targets
β2-adrenergic receptor [1]
In Vivo
In vivo

The bronchoprotective half-life of abediterol in guinea pigs is 47 h for olodaterol. In anaesthetised dogs, olodaterol inhibits acetylcholine-induced bronchoconstriction, with ID40 (dose inhibiting bronchoconstriction by 40%) of 0.180 µg/kg. In parallel, effect on heart rate in dogs is measured, showing a safety index (defined as the ratio of the maximal dose without effect on heart rate and the ID40) of 10.5.[2]
Animal Research Animal Models guinea pigs (bodyweight 340–580 g); male Beagle dogs
Dosages 0.03, 0.1, 0.3, 3, 10 and 30 mg/ml for guinea pigs; 0.1, 1, and 10 mg/kg for dogs
Administration aerosolised; respiratory pump
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03030638 Completed Pulmonary Disease Chronic Obstructive Boehringer Ingelheim|RTI health solutions US February 8 2017 --
NCT02969317 Completed Pulmonary Disease Chronic Obstructive Boehringer Ingelheim February 24 2017 Phase 1
NCT02172118 Completed Healthy Boehringer Ingelheim August 2009 Phase 1

Chemical lnformation & Solubility

Molecular Weight 386.44 Formula

C21H26N2O5
CAS No. 868049-49-4 SDF --
Smiles COC1=CC=C(CC(C)(C)NCC(O)C2=C3OCC(=O)NC3=CC(=C2)O)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 77 mg/mL ( (199.25 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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