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Paliperidone Palmitate

Name: Paliperidone Palmitate
Brand: Selleck Chemicals
SKU: S5624
Rating: 5 (1 reviews)

Synonyms: 9-hydroxyrisperidone palmitate

Catalog No.S5624 Purity: 99.06%

Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.

Paliperidone Palmitate Chemical Structure

CAS: 199739-10-1

Selleck's Paliperidone Palmitate has been cited by 1 publication

Purity & Quality Control

Batch: S562401 Ethanol] 3 mg/mL] false] DMSO] 1 mg/mL] false] Water] Insoluble] false Purity: 99.06%

99.06

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Biological Activity

Description	Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02532842	Completed	Schizophrenia	Janssen Pharmaceutica N.V. Belgium	July 2015	--
NCT01584466	Withdrawn	Schizophrenia	University of Maryland Baltimore	January 2014	Not Applicable
NCT01926912	Completed	Schizophrenia	Janssen-Cilag International NV	May 2013	--
NCT01211704	Withdrawn	Bipolar Disorder	University of Miami\|Ortho-McNeil Inc.	October 2010	Phase 4
NCT01051531	Completed	Schizophrenia	Johnson & Johnson Pte Ltd	April 2010	Phase 3

Chemical lnformation & Solubility

Molecular Weight	664.89	Formula	C₃₉H₅₇FN₄O₄
CAS No.	199739-10-1	SDF	--
Smiles	CCCCCCCCCCCCCCCC(=O)OC1CCCN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Ethanol : 3 mg/mL

DMSO : 1 mg/mL ( (1.5 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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