Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Quinestrol For research use only.

Quinestrol

Synonyms: Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566

Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.

Quinestrol Chemical Structure

Quinestrol Chemical Structure

CAS: 152-43-2

Purity & Quality Control

Batch: S367101 DMSO] 72 mg/mL] false] Ethanol] 72 mg/mL] false] Water] Insoluble] false Purity: 99.89%
99.89

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Biological Activity

Description Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.
In vitro
In vitro Quinestrol (17-alpha ethinylestradiol-3-cyclopentyl ether), a derivative of ethinylestradiol, is a long-acting synthetic estrogen. Its estrogenic activity is about 8 to 10 times that of its matrix, and it has strong antifertility effects[1].
In Vivo
In vivo Animal experiments show that after oral administration, quinestrol is absorbed by the gastrointestinal tract and stored in the adipose tissue; then it is gradually released into the bloodstream at low levels to maintain a long-lasting effective concentration. Male gerbils exposed to quinestrol show a significant decrease in epididymides, seminal vesicles, semen quality, and reproductive rates. Quinestrol treatment causes an imbalance in the oxidation and antioxidant system in blood and testicular tissue. Quinestrol induces ROS and simultaneously reduces antioxidant enzyme activity, leaving germ cells in their oxidation state, which results in spermatogenic cell damage. [1].
Animal Research Animal Models adult male gerbils
Dosages 3.5 and 35 mg/kg
Administration oral gavage

Chemical lnformation & Solubility

Molecular Weight 364.52 Formula

C25H32O2
CAS No. 152-43-2 SDF Download Quinestrol SDF
Smiles CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (197.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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