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Rotigotine

Synonyms: N-0923

Catalog No.S4274 Purity: 99.97%

Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

Rotigotine Chemical Structure

CAS: 99755-59-6

Selleck's Rotigotine has been cited by 1 publication

Purity & Quality Control

Batch: S427401 DMSO] 63 mg/mL] false] Ethanol] 63 mg/mL] false] Water] Insoluble] false Purity: 99.97%

99.97

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Biological Activity

Description

Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.

Targets

Dopamine receptor ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02728947	Completed	Parkinson''s Disease	Luye Pharma Group Ltd.	May 2016	Phase 1
NCT02070796	Completed	Healthy	UCB Pharma SA\|UCB Pharma	February 2014	Phase 1
NCT01675024	Completed	Healthy	UCB Pharma	August 2012	Phase 1
NCT02786667	Unknown status	Parkinson Disease\|Apathy	University Hospital Grenoble	June 2012	Phase 3
NCT01565018	Completed	Healthy Volunteers	UCB Pharma\|Otsuka Pharmaceutical Co. Ltd.	March 2012	Phase 1
NCT01536015	Terminated	Advanced Parkinson''s Disease	UCB Pharma	January 2012	Phase 3

Chemical lnformation & Solubility

Molecular Weight	315.47	Formula	C₁₉H₂₅NOS
CAS No.	99755-59-6	SDF	Download Rotigotine SDF
Smiles	CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 63 mg/mL ( (199.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 63 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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