Home Neuronal Signaling Adrenergic Receptor agonist Salmeterol For research use only.

Salmeterol

Synonyms: Astmerole, GR-33343X, SN408D

Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).

Salmeterol Chemical Structure

Salmeterol Chemical Structure

CAS: 89365-50-4

Selleck's Salmeterol has been cited by 3 publications

Purity & Quality Control

Batch: S552701 DMSO] 83 mg/mL] false] Ethanol] 83 mg/mL] false] Water] Insoluble] false Purity: 99.9%
99.9

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Biological Activity

Description Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
Targets
β2-adrenergic receptor [1]
(Cell-free)
1.5 nM(Ki)
In vitro
In vitro Salmeterol is highly lipophilic and diffuses through the lipid bilayer in muscle cell membranes to reach the β2-ARs, explaining its slow onset and long duration of action[2]. Salmeterol has been found to cause a dose-dependent increase in cAMP levels in neutrophils, an effect that is expected to reduce neutrophil-endothelial cell adhesion through inhibition of neutrophil Mac-1 cell surface expression[3].
In Vivo
In vivo Salmeterol decreases the production of pro-inflammatory cytokines in a model of allergen-challenged mice that expressed tumor-necrosis factor-alpha, interleukin-1 and interleukin-6[2]. Salmeterol inhibits lipopolysaccharide-induced neutrophil recruitment to the lungs by a mechanism that possibly in part is mediated by an effect on neutrophil CD11b[3].
Animal Research Animal Models Female C57BL/6 mice (8 wk old)
Dosages 0.005-5 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05085587 Unknown status Bioequivalence|Asthma Respirent Pharmaceuticals Co Ltd.|Becro Ltd. October 1 2021 Phase 1
NCT04503460 Recruiting Asthma Imperial College London|European Research Council July 23 2021 Phase 4
NCT03755544 Completed Asthma|Chronic Obstructive Pulmonary Disease Orion Corporation Orion Pharma January 16 2019 --

Chemical lnformation & Solubility

Molecular Weight 415.57 Formula

C25H37NO4
CAS No. 89365-50-4 SDF --
Smiles C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 83 mg/mL ( (199.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble


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In vivo
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