Home Neuronal Signaling Adrenergic Receptor antagonist Terazosin HCl Dihydrate For research use only.

Terazosin HCl Dihydrate

Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).

Terazosin HCl Dihydrate Chemical Structure

Terazosin HCl Dihydrate Chemical Structure

CAS: 70024-40-7

Selleck's Terazosin HCl Dihydrate has been cited by 1 publication

Purity & Quality Control

Batch: S205901 DMSO] 26 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.97%
99.97

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Biological Activity

Description Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).
Targets
α-adrenergic receptor [1]
In vitro
In vitro Terazosin results in a significant loss of cell viability, via induction of apoptosis in a dose-dependent manner in prostate cancer cells. Terazosin suppresses prostate growth potentially via α 1-adrenoceptor-independent actions gains further support from another study documenting that Doxazosin inhibits proliferation of human vascular smooth muscle cells independently of an antagonistic effect on α1-adrenoceptor. [1] Terazosin blocks HERG currents in Xenopus oocytes with IC50 of 113.2 mM, while Terazosin blocks HERG channel inhibition in human HEK 293 cells with IC50 of 17.7 mM. [2] Terazosin or genistein treatment inhibits the growth of DU-145 cells in a dose-dependent manner, whereas has no effect on normal prostate epithelial cells. Terazosin results in the genistein-induced arrest of DU-145 cells in G2/M phase being overridden and an increase in apoptotic cells, as evidenced by procaspase-3 activation and PARP cleavage. [3] Terazosin induces cytotoxicity in PC-3 and human benign prostatic cells with an IC50 of more than 100 mM. [4]
In Vivo
In vivo Terazosin significantly inhibits vascular endothelial growth factor induced angiogenesis in nude mice with an IC50 of 7.9 mM, showing that it has a more potent anti-angiogenic than cytotoxic effect. Terazosin also effectively inhibits vascular endothelial growth factor induced proliferation and tube formation in cultured human umbilical vein endothelial cells (IC50 9.9 and 6.8 mM, respectively). [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04760860 Not yet recruiting Dementia With Lewy Bodies Qiang Zhang|University of Iowa October 2024 Phase 1|Phase 2
NCT04551040 Active not recruiting Healthy University of Iowa|Michael J. Fox Foundation for Parkinson''s Research March 26 2021 Phase 1
NCT04386317 Recruiting REM Sleep Behavior Disorder|Pre-motor Parkinson''s Disease|Symptomatic Parkinson Disease Cedars-Sinai Medical Center November 1 2020 Phase 2
NCT00449683 Completed Hyperhidrosis Thomas Jefferson University|National Alliance for Research on Schizophrenia and Depression March 2007 Phase 4
NCT00237510 Completed Antidepressant Induced Excessive Sweating Thomas Jefferson University May 2005 Not Applicable
NCT02244333 Completed Prostatic Hyperplasia Boehringer Ingelheim February 2004 --

Chemical lnformation & Solubility

Molecular Weight 459.92 Formula

C19H25N5O4.HCl.2H2O
CAS No. 70024-40-7 SDF Download Terazosin HCl Dihydrate SDF
Smiles COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.O.O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 26 mg/mL ( (56.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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