Home Neuronal Signaling Adrenergic Receptor antagonist Tolazoline HCl For research use only.

Tolazoline HCl

Synonyms: Imidaline hydrochloride,NSC35110 hydrochloride

Tolazoline(Imidaline hydrochloride,NSC35110 hydrochloride) is a non-selective competitive α-adrenergic receptor antagonist.

Tolazoline HCl Chemical Structure

Tolazoline HCl Chemical Structure

CAS: 59-97-2

Selleck's Tolazoline HCl has been cited by 1 publication

Purity & Quality Control

Batch: S412401 DMSO] 39 mg/mL] false] Water] 39 mg/mL] false] Ethanol] 39 mg/mL] false Purity: 99.88%
99.88

Other Adrenergic Receptor Products

Related compound libraries

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description Tolazoline(Imidaline hydrochloride,NSC35110 hydrochloride) is a non-selective competitive α-adrenergic receptor antagonist.
Targets
α-adrenergic receptor [1]
In vitro
In vitro

Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN). Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.[1] Tolazoline is not as broadly effective as SNP against all spasmogens investigated. However, it may be effective in counteracting alpha-adrenoceptor-mediated vasospasm in human radial arteries. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00574184 Completed Erectile Dysfunction University of California Davis August 2005 --

Chemical lnformation & Solubility

Molecular Weight 196.68 Formula

C10H12N2.HCl
CAS No. 59-97-2 SDF Download Tolazoline HCl SDF
Smiles C1CN=C(N1)CC2=CC=CC=C2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (198.29 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 39 mg/mL

Ethanol : 39 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Tolazoline HCl | Tolazoline HCl ic50 | Tolazoline HCl price | Tolazoline HCl cost | Tolazoline HCl solubility dmso | Tolazoline HCl purchase | Tolazoline HCl manufacturer | Tolazoline HCl research buy | Tolazoline HCl order | Tolazoline HCl mouse | Tolazoline HCl chemical structure | Tolazoline HCl mw | Tolazoline HCl molecular weight | Tolazoline HCl datasheet | Tolazoline HCl supplier | Tolazoline HCl in vitro | Tolazoline HCl cell line | Tolazoline HCl concentration | Tolazoline HCl nmr