Home Immunology & Inflammation Anti-infection inhibitor Antimonyl potassium tartrate trihydrate For research use only.

Antimonyl potassium tartrate trihydrate

Synonyms: Tartar emetic

Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Antimonyl potassium tartrate trihydrate Chemical Structure

Antimonyl potassium tartrate trihydrate Chemical Structure

CAS: 28300-74-5

Purity & Quality Control

Batch: S454901 Water] 100 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.23%
99.23

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Biological Activity

Description Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
In Vivo
In vivo i.p. administration of the drug was much more toxic, resulting in the deaths of rats administered 22 mg/kg; kidney and liver lesions were found in these rats. In mice, i.p. administration of APT caused deaths and liver lesions at dose levels one-fourth of those that caused similar effects by oral administration. Rats were more sensitive than mice to the toxic effects of APT, exhibiting dose-related mortality and reduction in body weight[1].
Animal Research Animal Models F344/N rats and B6C3F1 mice
Dosages 0, 1.5, 3, 6, 11, or 22 mg/kg in rats and 0, 6, 13, 25, 50, or 100 mg/kg in mice for i.p. injection; 0, 16, 28, 59, 94, or 168 mg/kg in rats and 0, 59, 98, 174, 273, or 407 mg/kg in mice for drinking water doses.
Administration i.p. injection or oral administration（by drinking water）

Chemical lnformation & Solubility

Molecular Weight 667.87 Formula

C8H4O12Sb2.3H2O.2K
CAS No. 28300-74-5 SDF Download Antimonyl potassium tartrate trihydrate SDF
Smiles C12C(O[Sb]3OC(C(O[Sb](O1)OC2=O)C(=O)[O-])C(=O)O3)C(=O)[O-].O.O.O.[K+].[K+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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