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Chlorhexidine 2HCl

Name: Chlorhexidine 2HCl
Brand: Selleck Chemicals
SKU: S3067
Rating: 5 (1 reviews)

Synonyms: NSC-185

Catalog No.S3067 Purity: 99.75%

Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.

Chlorhexidine 2HCl Chemical Structure

CAS: 3697-42-5

Selleck's Chlorhexidine 2HCl has been cited by 1 publication

Purity & Quality Control

Batch: S306701 DMSO] 80 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.75%

99.75

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Biological Activity

Description	Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.

In vitro
In vitro	Chlorhexidine is a chemical antiseptic.It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06163469	Not yet recruiting	Neurogenic Bladder\|Urinary Retention	Yale University\|Irrimax Corporation	January 1 2024	Not Applicable
NCT06112626	Not yet recruiting	Infections	Duke University\|Advanced Care Planning Decisions	November 1 2023	Not Applicable
NCT03700788	Not yet recruiting	Apical Periodontitis	University of Southern California	May 30 2023	Phase 3
NCT05995080	Recruiting	Central Venous Catheter Related Bloodstream Infection\|Catheter-Related Infections\|Bloodstream Infection Due to Central Venous Catheter	Istanbul Medeniyet University	May 1 2022	Not Applicable

References

Chemical lnformation & Solubility

Molecular Weight	578.37	Formula	C₂₂H₃₀C_l2N_10.2HCl
CAS No.	3697-42-5	SDF	Download Chlorhexidine 2HCl SDF
Smiles	C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.Cl.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 80 mg/mL ( (138.31 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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