Home NF-κB NF-κB inhibitor - Interleukins inhibitor - ERK inhibitor - TNF-alpha inhibitor Methylthiouracil For research use only.

Methylthiouracil

Synonyms: NSC-193526, NSC-9378,MTU

Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

Methylthiouracil Chemical Structure

Methylthiouracil Chemical Structure

CAS: 56-04-2

Purity & Quality Control

Batch: S313801 DMSO] 28 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.53%
99.53

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Biological Activity

Description Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
Targets
TNF-α [3] IL-6 [3] NF-κB [3] ERK1/2 [3]
In vitro
In vitro

Methylthiouracil acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. Methylthiouracil is also used in combination with radioactive iodine.

Chemical lnformation & Solubility

Molecular Weight 142.18 Formula

C5H6N2OS
CAS No. 56-04-2 SDF Download Methylthiouracil SDF
Smiles CC1=CC(=O)NC(=S)N1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 28 mg/mL ( (196.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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