Home Microbiology Anti-infection chemical Sulfaguanidine For research use only.

Sulfaguanidine

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

Sulfaguanidine Chemical Structure

Sulfaguanidine Chemical Structure

CAS: 57-67-0

Purity & Quality Control

Batch: S417501 DMSO] 43 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.01%
99.01

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Biological Activity

Description Sulfaguanidine is a sulfonamide used as an anti-infective agent.
In vitro
In vitro Sulfaguanidine is the first sulfonamide designed to treat enteric infections. Sulfaguanidine have been found to be particularly effective in preventing the growth of the gram-negative intestinal bacilli. It is a useful tool for the inhibition of synthesis of nutritional factors by intestinal bacteria. [1]
In Vivo
In vivo In adult rats, sulfaguanidine's elimination from plasma, after intravenous administration of 2.5 or 25 mg/kg doses, while its plasma concentration after oral administration of 25 mg/kg doses. Neonatal rats displayed a lower elimination of sulfaguanidine than adult rats. Comparison of the drug's gastrointestinal absorption shows that the maximum plasma concentration after oral administration is significantly higher for neonatal than for adult rats. However, there is no significant difference between the times required to reach maximum plasma concentrations. The absolute bioavailability (57.86%) in neonatal rats is approximately five times that (12.76%) in adult rats. Thus, sulfaguanidine is poorly absorbed by adult rats, but is efficiently absorbed by immature gastrointestines of neonatal rats. [1]

Chemical lnformation & Solubility

Molecular Weight 214.24 Formula

C7 H10N4O2S
CAS No. 57-67-0 SDF Download Sulfaguanidine SDF
Smiles C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (200.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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