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Dp44mT

Dp44mT is a potent iron chelator, which shows selective antitumor activity.

Dp44mT Chemical Structure

Dp44mT Chemical Structure

CAS: 152095-12-0

Selleck's Dp44mT has been cited by 4 publications

Purity & Quality Control

Batch: S790901 DMSO] 57 mg/mL] false] Ethanol] 47 mg/mL] false] Water] Insoluble] false Purity: 98.99%
98.99

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Biological Activity

Description Dp44mT is a potent iron chelator, which shows selective antitumor activity.
Targets
iron [1]
In vitro
In vitro Dp44mT shows pronounced antiproliferative effects in SK-N-MC, SK-Mel-28, and MCF-7 cells with IC50 of 30 nM, 60 nM, and 60 nM, respectively, while no effects on normal MRC-5 fibroblasts. Dp44mT inhibits cellular Fe uptake from Fe-Tf in SK-N-MC neuroepithelioma and M109 cells, and induces cell apoptosis. [1] In MDA-MB-231 cells, Dp44mT specifically targets topoisomerase topo2α, and thus causes DNA damage. [2] Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp). [3]
Cell Research Cell lines SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells
Concentrations ~25 μM
Incubation Time 72 h
Method Cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C。 The effect of the chelators on proliferation is examined using the MTT assay.
In Vivo
In vivo In CD2F1 mice bearing M109 tumors, Dp44mT (0.4 mg/kg, i.v.) inhibits tumor growth in a dose-dependent manner. [1]
Animal Research Animal Models CD2F1 mice bearing M109 tumors
Dosages 04 mg/kg, twice daily
Administration i.v.

Chemical lnformation & Solubility

Molecular Weight 285.37 Formula

C14H15N5S
CAS No. 152095-12-0 SDF Download Dp44mT SDF
Smiles CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 57 mg/mL ( (199.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 47 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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