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Troxipide

Name: Troxipide
Brand: Selleck Chemicals
SKU: S4128
Rating: 5 (1 reviews)

Synonyms: KU 54

Catalog No.S4128 Purity: 99.91%

Troxipide(KU 54) is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum.

Troxipide Chemical Structure

CAS: 30751-05-4

Selleck's Troxipide has been cited by 1 publication

Purity & Quality Control

Batch: S412801 DMSO] 18 mg/mL] false] Ethanol] 3 mg/mL] false] Water] Insoluble] false Purity: 99.91%

99.91

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Biological Activity

Description	Troxipide(KU 54) is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum.

In vitro
In vitro	Troxipide is a novel antiulcer compound which has inhibitory effects on human neutrophil migration and activation induced by various stimulants.^[1] Troxipide is a new gastric cytoprotective agent, which neither inhibits acid secretion nor has acid neutralizing activity, but has been clinically proven to heal gastritis and gastric ulcers. Troxipide is shown to inhibit neutrophil mediated inflammation and oxidative stress in addition to improving the gastric mucus composition and output. Furthermore, it is found to increase the secretion of cytoprotective prostaglandins. The gastric mucosal metabolism and blood flow are also enhanced by Troxipide. ^[2]

References

Chemical lnformation & Solubility

Molecular Weight	294.35	Formula	C₁₅H₂₂N₂O₄
CAS No.	30751-05-4	SDF	Download Troxipide SDF
Smiles	COC1=CC(=CC(=C1OC)OC)C(=O)NC2CCCNC2
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 18 mg/mL ( (61.15 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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