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Sodium Nitroprusside Dihydrate

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

Sodium Nitroprusside Dihydrate Chemical Structure

Sodium Nitroprusside Dihydrate Chemical Structure

CAS: 13755-38-9

Selleck's Sodium Nitroprusside Dihydrate has been cited by 2 publications

Purity & Quality Control

Batch: S405901 DMSO] 60 mg/mL] false] Water] 60 mg/mL] false] Ethanol] Insoluble] false Purity: 99.7%
99.7

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Biological Activity

Description Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
Targets
guanylate cyclase [1]
In vitro
In vitro Sodium Nitroprusside is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate. [1] Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells. [2]
In Vivo
In vivo Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05277922 Completed Study Vasodilatory Effects of C21 Vicore Pharma AB|CTC Clinical Trial Consultants AB April 28 2022 Phase 1
NCT04303689 Completed Essential Hypertension University of Copenhagen|University of Aarhus August 1 2020 Not Applicable
NCT04321434 Terminated Coronary Microvascular Disease|Microvascular Disease|Ischemic Heart Disease Université Libre de Bruxelles December 1 2016 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 297.95 Formula

C5H4FeN6Na2O3
CAS No. 13755-38-9 SDF --
Smiles [C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.O.O.[Na+].[Na+].[Fe+4]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 60 mg/mL ( (201.37 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 60 mg/mL

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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