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Dimesna

Synonyms: BNP-7787

Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity.

Dimesna Chemical Structure

Dimesna Chemical Structure

CAS: 16208-51-8

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity.
In vitro
In vitro Dimesna modulates paclitaxel-induced hyperpolymerization of MTP in a dose-dependent manner, and mesna, an in vivo metabolite of Dimesna, protects against time-dependent cisplatin-induced inactivation of MTP. [1] Dimesna -mediated prevention or mitigation of cisplatin-induced nephrotoxicity may involve aminopeptidase N (APN) inhibition by certain Dimesna -derived esna-disulfide heteroconjugates and appears correlated to the presence of a glycinate moiety and/or an anionic group. Two general mechanisms for Dimesna -mediated nephroprotection of cisplatin-induced nephrotoxicity involving the gamma-glutamyl transpeptidase (GGT), APN and cysteine-conjugated-β-lyase (CCBL) nephrotoxigenic pathway are proposed which acting in a concerted and/or synergistic manner, and thereby prevent or mitigate cisplatin-induced renal toxicity. [2] Mesna and its dimer, Dimesna, are coadministered for mitigation of ifosfamide- and cisplatin-induced toxicities, respectively. Dimesna is selectively reduced to mesna in the kidney, producing its protective effects. In vitro screens of uptake and efflux transporters reveal renal organic anion transporters OAT1, OAT3, and OAT4 are responsible for kidney-specific uptake of Dimesna. Uptake of Dimesna by OAT1, OAT3, and OAT4 is determined to be saturable with KM of 636 μM, 390 μM and 590 μM, respectively. [3]
In Vivo
In vivo Tumors of urinary bladder induced by cyclophosphamide (CP) in rats can be significantly reduced by Dimesna administration in a dose-related manner. [4]
Animal Research Animal Models CP treated Sprague-Dawley rats
Dosages 12 or 35 mg/kg
Administration Orally five times a week

Chemical lnformation & Solubility

Molecular Weight 326.34 Formula

C4H8Na2O6S4
CAS No. 16208-51-8 SDF Download Dimesna SDF
Smiles C(CS(=O)(=O)[O-])SSCCS(=O)(=O)[O-].[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (199.17 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 65 mg/mL

Ethanol : Insoluble


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In vivo
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