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L-Glutamine

L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.

L-Glutamine Chemical Structure

L-Glutamine Chemical Structure

CAS: 56-85-9

Selleck's L-Glutamine has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.86%
99.86

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Biological Activity

Description L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.
In vitro
In vitro L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4]
In Vivo
In vivo L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04785989 Recruiting Chronic Lymphocytic Leukemia University of Wisconsin Madison June 13 2022 --
NCT05494541 Completed Sickle Cell Disease Novartis Pharmaceuticals|Novartis August 30 2021 --
NCT05833022 Completed Sickle Cell Disease Novartis Pharmaceuticals|Novartis July 30 2021 --
NCT04634539 Active not recruiting Advanced Pancreatic Adenocarcinoma|Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma Jun Gong MD|Emmaus Medical Inc.|Cedars-Sinai Medical Center May 13 2021 Phase 1
NCT04684381 Completed Sickle Cell Disease|Pharmacokinetics Emmaus Medical Inc. January 4 2021 Phase 4
NCT05106101 Completed Diverticulosis Colonic Emmaus Medical Inc. July 19 2019 Phase 1

Chemical lnformation & Solubility

Molecular Weight 146.14 Formula

C5H10N2O3
CAS No. 56-85-9 SDF Download L-Glutamine SDF
Smiles C(CC(=O)N)C(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 29 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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