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Potassium Iodide

Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.

Potassium Iodide Chemical Structure

Potassium Iodide Chemical Structure

CAS: 7681-11-0

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Biological Activity

Description Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.
In vitro
In vitro Iodine induces abnormal morphologic changes of cells, inhibited cell proliferation, and increases apoptosis rate in rat aorta endothelial cells. Iodine also reduces the activity of SOD, GSH-Px, and concentrations of GSH and increases the concentrations of MDA and protein carbonyl in a dose-dependent manner. Excess iodine decreased the activity of eNOS and increased the activity of iNOS and the expression of ICAM-1 and VCAM-1 in culture medium. Excess iodine exposure increases oxidative stress, causes damage of vascular endothelial cells, and altered the expression of adhesion factors and the activity of NOS. [1] Potassium iodide increases avidity of some immune reactions including C-mediated cell lysis mediated by altered access of C-binding receptors. [2] Potassium iodide (≥50 mM) increases lipid peroxidation in concentration-dependent manner. Potassium iodide (25 mM) reduces Fenton reaction-induced lipid peroxidation. [3] Potassium iodide is able to eliminate E faecalis from bovine root dentin when used with a 15-minute contact time. [4]
In Vivo
In vivo Potassium Iodide decreases Schiff's bases (SB) concentrations in liver and lung homogenates after the administration of PTU but, unexpectedly, the level of SB increases in kidney homogenates of Wistar rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01301768 Withdrawn Dietary Intervention|Pregnancy Jail|Iodine Deficiency Fundacio d''Investigacio en Atencio Primaria Jordi Gol i Gurina November 2008 Not Applicable
NCT00379535 Terminated Pregnancy University Hospital Toulouse|Ministry of Health France December 2006 Phase 3

Chemical lnformation & Solubility

Molecular Weight 166 Formula

K+I-
CAS No. 7681-11-0 SDF Download Potassium Iodide SDF
Smiles [K+].[I-]
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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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