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Benzoic Acid

Name: Benzoic Acid
Brand: Selleck Chemicals
SKU: S4161

Synonyms: FEMA 2131

Catalog No.S4161 Purity: 99.77%

Benzoic acid (FEMA 2131) is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.

Benzoic Acid Chemical Structure

CAS: 65-85-0

Purity & Quality Control

Batch: S416101 DMSO] 24 mg/mL] false] Ethanol] 24 mg/mL] false] Water] Insoluble] false Purity: 99.77%

99.77

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Biological Activity

Description	Benzoic acid (FEMA 2131) is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.

In vitro
In vitro	Benzoic acid transports through human skin membranes with the mean maximum absorption rate of 16.54 μg/cm²/h, while the amount in the receptor fluid after 24 hours is 70.6% of the dose applied. The transport of [14C]benzoic acid is significantly inhibited carbonylcyanide p-trifluoromethoxyphenylhydrazone and nigericin, the direct driving force for benzoic acid transport is suggested to be the inwardly directed proton gradient. ^[1] Benzoic acid enters the diet as a natural constituent in plants, with high amounts found in fruits and berries and as a result of the widespread use of monosodium benzoate as a food preservative. Benzoic acid and para-t-butylbenzoate are most potent and acetyl CoA carboxylase (EC 6.4.1.2) appeared to be the target of inhibition. Benzoic acid readily enters the cell to undergo intracellular ionization with a substantial lowering of cytosolic pH and ATP levels under acidic growth conditions. Benzoic acid is oxidized by hydroxy radicals produced by stimulated polymorphonuclear cells oxidize. ^[2] The photometabolism of Benzoic and 4-hydroxybenzoic acids by whole cells is inhibited by the presence of exogenous fatty acids. Benzoic acid enters the anaerobic degradation as follow: initial activation to form benzoyl-Coenzyme A, reduction of the aromatic nucleus--a reaction that has only recently been demonstrated in vitro--and the subsequent degradation of the alicyclic intermediates. ^[3] For Benzoic acid, there is no differences between the mean absorption through human skin and the one rat study, and skin thickness only slightly influences the absorption of Benzoic acid. ^[4]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01527123	Completed	Acne Vulgaris	GlaxoSmithKline	February 28 2012	Phase 1
NCT01161836	Completed	Advanced Solid Tumors	Sanofi	July 2010	Phase 1

References

[4] van de Sandt JJ, et al. Regul Toxicol Pharmacol, 2004, 39(3), 271-281.

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Chemical lnformation & Solubility

Molecular Weight	122.12	Formula	C₇H₆O₂
CAS No.	65-85-0	SDF	Download Benzoic Acid SDF
Smiles	C1=CC=C(C=C1)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 24 mg/mL ( (196.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 24 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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