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Bisacodyl

Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.

Bisacodyl Chemical Structure

Bisacodyl Chemical Structure

CAS: 603-50-9

Purity & Quality Control

Batch: S404701 DMSO] 72 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.9%
99.9

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Biological Activity

Description Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
In vitro
In vitro Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells. [1]
In Vivo
In vivo Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats. [1] Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL. [2] Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods. [3] Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content. [4] Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05770960 Completed Opioid-Induced Constipation Universitaire Ziekenhuizen KU Leuven June 27 2018 Phase 4
NCT03279341 Completed Chronic Constipation University Hospital Gasthuisberg December 3 2012 Phase 4
NCT01424228 Completed Constipation Shire|Takeda April 6 2011 Phase 4
NCT01147926 Completed Male Subjects With Chronic Constipation Shire|Takeda September 23 2010 Phase 3

Chemical lnformation & Solubility

Molecular Weight 361.39 Formula

C22H19NO4
CAS No. 603-50-9 SDF Download Bisacodyl SDF
Smiles CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (199.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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