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Cilastatin

Synonyms: MK0791

Cilastatin(MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.

Cilastatin Chemical Structure

Cilastatin Chemical Structure

CAS: 82009-34-5

Selleck's Cilastatin has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.95%
99.95

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Biological Activity

Description Cilastatin(MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.
Targets
dehydropeptidase-I [1] leukotriene D4 dipeptidase [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04802863 Completed Bacterial Infections Evopoint Biosciences Inc. March 25 2021 Phase 1
NCT04801043 Completed Bacterial Infections Evopoint Biosciences Inc. March 2 2021 Phase 1
NCT04787562 Completed Bacterial Infections Evopoint Biosciences Inc. February 25 2021 Phase 1
NCT03595189 Completed Dose Finding Study Spherium Biomed|Hospital Universitario La Paz June 19 2018 Phase 1
NCT03230916 Completed Suspected or Documented Gram-negative Bacterial Infection Merck Sharp & Dohme LLC November 6 2017 Phase 1

Chemical lnformation & Solubility

Molecular Weight 358.45 Formula

C16H26N2O5S
CAS No. 82009-34-5 SDF --
Smiles CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)O)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 72 mg/mL ( (200.86 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 7 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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