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Clopamide

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.

Clopamide Chemical Structure

Clopamide Chemical Structure

CAS: 636-54-4

Purity & Quality Control

Batch: Purity: 99.68%
99.68

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Biological Activity

Description Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.
In vitro
In vitro Clopamide exhibits no inhibition of LDL peroxidation induces either by copper ions or by cultured endothelial cells. [1] Clopamide results in True Tubular Excretion Fraction (TTEF) in renal tubular cells. [2]
In Vivo
In vivo Clopamide (40 mg, orally) combined with Chloramphenicol (1 g, orally) and Ethacrynic acid (150 mg, orally) increases the urinary excretion of chloramphenicol and its metabolites (aryl amines and total nitro compounds) in vivo. [3]

Chemical lnformation & Solubility

Molecular Weight 345.84 Formula

C14H20ClN3O3S
CAS No. 636-54-4 SDF Download Clopamide SDF
Smiles CC1CCCC(N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 69 mg/mL ( (199.51 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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