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Dansylcadaverine (Monodansyl cadaverine)

Synonyms: MDC, Monodansyl cadaverine

Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.

Dansylcadaverine (Monodansyl cadaverine) Chemical Structure

Dansylcadaverine (Monodansyl cadaverine) Chemical Structure

CAS: 10121-91-2

Purity & Quality Control

Batch: E045101 DMSO] 67 mg/mL] false] Ethanol] 8 mg/mL] false] Water] Insoluble] false Purity: 98.95%
98.95

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Biological Activity

Description

Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.
In vitro
In vitro

Dansylcadaverine is an autofluorescent compound used for the labeling of autophagic vacuoles, which is able to serve as a substrate for transglutaminases and to block competitively the crosslinking of fibrin molecules.[3]
Cell Research Cell lines MCF7 cells
Concentrations 50 mM
Incubation Time 15 min
Method

MCF7 cells (2.4 ×104 ) are seeded into 35 mm plates. After 24 h incubation, CuO NPs are added with an increasing concentration in the presence or absence of 3-MA for different time periods. The cells are then incubated with 50 mM monodansylcadaverine at 37℃ for 15 min and washed with 1×PBS three times with 5 min interval. Finally, the cells are observed under a fluorescence microscope.

Chemical lnformation & Solubility

Molecular Weight 335.46 Formula

C17H25N3O2S
CAS No. 10121-91-2 SDF --
Smiles CN(C)C1=CC=CC2=C(C=CC=C12)[S](=O)(=O)NCCCCCN
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 67 mg/mL ( (199.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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