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Dexrazoxane

Synonyms: ICRF-187

Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Dexrazoxane Chemical Structure

Dexrazoxane Chemical Structure

CAS: 24584-09-6

Selleck's Dexrazoxane has been cited by 9 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

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Biological Activity

Description Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.
In vitro
In vitro

Topoisomerase 2 (Top2) inhibition with dexrazoxane combined with dBET6 in HeLa cells increases DNA damage signaling at proximal time points.[1]
Cell Research Cell lines HeLa cells
Concentrations 50 μM J60
Incubation Time 4 h
Method

HeLa cells are treated with 50 μM dexrazoxane for 4 h. Cell lysates are used for detecting the levels of BRD4, RNAPIIpS2 and γH2AX by western blots.
In Vivo
In vivo

Dexrazoxane prevents doxorubicin induced late-onset cardiomyopathy and also protected the cardiac mitochondria from acquired ultrastructural, genetic and functional damage.

Chemical lnformation & Solubility

Molecular Weight 268.27 Formula

C11H16N4O4
CAS No. 24584-09-6 SDF --
Smiles CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 54 mg/mL ( (201.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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