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Dihydroxyfumaric acid hydrate

Name: Dihydroxyfumaric acid hydrate
Brand: Selleck Chemicals
SKU: S2990

Synonyms: DHF

Catalog No.S2990 Purity: 99.92%

Dihydroxyfumaric acid hydrate (DHF) is an endogenous metabolite. The diester derivative of dihydroxyfumaric acid hydrate (DHF) has been used exclusively as an electrophile in organic synthesis.

Dihydroxyfumaric acid hydrate Chemical Structure

CAS: 199926-38-0

Purity & Quality Control

Batch: S299001 DMSO] 33 mg/mL] false] Ethanol] 33 mg/mL] false] Water] Insoluble] false Purity: 99.92%

99.92

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Biological Activity

Description	Dihydroxyfumaric acid hydrate (DHF) is an endogenous metabolite. The diester derivative of dihydroxyfumaric acid hydrate (DHF) has been used exclusively as an electrophile in organic synthesis.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06006559	Recruiting	Dengue	Novartis Pharmaceuticals\|Novartis	January 12 2024	Phase 2
NCT04048837	Completed	Dengue Hemorrhagic Fever\|Dengue Shock Syndrome\|Severe Dengue	National University Hospital Singapore\|Tan Tock Seng Hospital\|Ng Teng Fong General Hospital	July 30 2018	--
NCT01030211	Completed	Dengue Fever	Tan Tock Seng Hospital\|Singapore General Hospital\|Changi General Hospital\|National University Hospital Singapore\|University of Malaya	January 2010	Not Applicable
NCT00946218	Completed	Dengue Fever	St. Jude Children''s Research Hospital	July 2009	--

References

[1] George Ward, et al. J Org Chem. 2018 Dec 7;83(23):14219-14233.

Chemical lnformation & Solubility

Molecular Weight	166.09	Formula	C₄H₆O₇
CAS No.	199926-38-0	SDF	--
Smiles	O.OC(=O)C(/O)=C(\O)C(O)=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 33 mg/mL ( (198.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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