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DL-Glutamine

Synonyms: Glutamin, 2-amino-4-carbamoylbutanoic acid

DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.

DL-Glutamine Chemical Structure

DL-Glutamine Chemical Structure

CAS: 6899-04-3

Purity & Quality Control

Batch: S396301 Water] 29 mg/mL] false] DMSO] Insoluble] false] ] ] false Purity: 98%
98

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Biological Activity

Description DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.
In vitro
In vitro L-Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, as well as providing a source of carbons for oxidation in some cell. Glutamine has been reported to enhance many functional parameters of immune cells such as T-cell proliferation, B-lymphocyte differentiation, macrophage phagocytosis, antigen presentation and cytokine production plus neutrophil superoxide production and apoptosis. Glutamine itself may act as a key precursor for nucleic acids and nucleotides in glutamine-consuming cells, but in many physiological circumstances acts to provide glutamate, which appears to promote a wider array of metabolic functions compared to glutamine[1].
In Vivo
In vivo L-Glutamate is the most abundant intracellular amino acid whereas L-glutamine is the most abundant extracellular amino acid in vivo. Glutamine metabolism is zoned in the liver so that glutamine is taken up by the periportal cells of the liver in which there is a relatively high glutaminase activity and the ammonia produced directed towards carbamoyl phosphate synthesis[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05312736 Recruiting Gyrate Atrophy|Gyrata of Choroid and Retina; Atrophy|Ornithine-δ-aminotransferase|OAT|Chorioretinal Degeneration Jaeb Center for Health Research|Conquering Gyrate Atrophy Foundation|Food and Drug Administration (FDA)|Department of Health and Human Services November 21 2023 --
NCT05972291 Recruiting Gulf War Illness|Irritable Bowel Syndrome|Gastrointestinal Symptoms VA Office of Research and Development October 16 2023 Not Applicable
NCT05778461 Not yet recruiting Liver Failure Acute Institute of Liver and Biliary Sciences India March 15 2023 Not Applicable
NCT05706389 Recruiting Aging National University of Singapore|Agency for Science Technology and Research|AMILI Pte. Ltd. February 24 2023 Phase 2
NCT05631327 Recruiting Advanced Solid Tumor|Metastatic Solid Tumor Jazz Pharmaceuticals December 19 2022 Phase 1

Chemical lnformation & Solubility

Molecular Weight 146.14 Formula

C5H10N2O3
 
CAS No. 6899-04-3 SDF Download DL-Glutamine SDF
Smiles C(CC(=O)N)C(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 29 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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