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Famprofazone

Name: Famprofazone
Brand: Selleck Chemicals
SKU: S4327

Synonyms: Geodowin, FA, Famprofazonum

Catalog No.S4327 Purity: 98%

Famprofazone (Geodowin, FA, Famprofazonum) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series. Famprofazone is an analgesic used for fever and pain relief.

Famprofazone Chemical Structure

CAS: 22881-35-2

Purity & Quality Control

Batch: S432701 Ethanol] 12 mg/mL] false] DMSO] Insoluble] false] Water] Insoluble] false Purity: 98%

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Biological Activity

Description	Famprofazone (Geodowin, FA, Famprofazonum) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series. Famprofazone is an analgesic used for fever and pain relief.

In vitro
In vitro	Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it. Famprofazone has occasionally been implicated in causing false positives on drug tests for amphetamines.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05940766	Not yet recruiting	Pediatric Oncology Patients With Risk for Infections	Insel Gruppe AG University Hospital Bern\|ETH Zurich	October 1 2024	Not Applicable
NCT05731375	Not yet recruiting	Doxorubicin Induced Cardiomyopathy\|Chemotherapeutic Toxicity\|B-cell Lymphoma\|T-cell Lymphoma	UMC Utrecht\|Julius Clinical	April 2024	--
NCT06078384	Not yet recruiting	Triple-negative Breast Cancer	UNICANCER\|MSD France\|Vall d''Hebron Institute of Oncology\|SOLTI Breast Cancer Research Group	February 1 2024	Phase 2
NCT05968703	Not yet recruiting	Parkinson''s Disease\|Mild Cognitive Impairment	Helen M. Bronte-Stewart\|National Institute of Neurological Disorders and Stroke (NINDS)\|Stanford University	February 2024	Not Applicable
NCT05996536	Recruiting	Lipodystrophy	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Institutes of Health Clinical Center (CC)	January 3 2024	--

References

[1] Elisangela de Souza Santos, et al. Talanta. 2019 Jan 1;191:545-552.

Chemical lnformation & Solubility

Molecular Weight	377.52	Formula	C₂₄H₃₁N₃O
CAS No.	22881-35-2	SDF	Download Famprofazone SDF
Smiles	CC(C)C1=C(N(N(C1=O)C2=CC=CC=C2)C)CN(C)C(C)CC3=CC=CC=C3
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Ethanol : 12 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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