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Iron sucrose

Name: Iron sucrose
Brand: Selleck Chemicals
SKU: S3729

Synonyms: Iron saccharate, Sucroferric oxyhydroxide

Catalog No.S3729 Purity: 99.22%

Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.

Iron sucrose Chemical Structure

CAS: 8047-67-4

Purity & Quality Control

Suerose Assay ≥85%, Iron Assay 5.0-6.0%
Finest quality approved by Nature Medicine
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SDS

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Biological Activity

Description	Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.

In vitro
In vitro	Iron sucrose (0.01 mg/mL) used as an additive to culture medium for 24 h was cytotoxic to human peritoneal mesothelial cells in in vitro culture as reflected by its effect on the cells' growth, viability and synthesis of IL-6; all these effects were dosedependent. At higher, concentrations cytotoxic effects of iron sucrose appeared. Toxic effect of iron towards the mesothelial cells may be linked to increased production of free radicals. Iron sucrose enters into the cytosol of the mesothelial cells, where it is probably transported in a process of endocytosis^[1].
Cell Research	Cell lines	human peritoneal mesothelial cells.
	Concentrations	0.01 mg/mL
	Incubation Time	24 h
	Method	--

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05921968	Not yet recruiting	Iron Deficiency Anemia	Ain Shams University	July 30 2023	Phase 4
NCT04304625	Recruiting	Postpartum Hemorrhage	University Hospital Bordeaux	August 7 2020	Phase 3
NCT03917394	Unknown status	Anemia Iron Deficiency	Peking Union Medical College Hospital	April 24 2019	--

References

[1] Breborowicz M, et al. Eur J Clin Invest. 2003, 33(12):1038-44.

Chemical lnformation & Solubility

Molecular Weight	736.06	Formula	C₁₈H₂₄Fe₂O₂₄
CAS No.	8047-67-4	SDF	Download Iron sucrose SDF
Smiles	C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.[Fe+3].[Fe+3]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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