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Pramoxine HCl

Synonyms: Pramocaine hydrochloride

Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.

Pramoxine HCl Chemical Structure

Pramoxine HCl Chemical Structure

CAS: 637-58-1

Selleck's Pramoxine HCl has been cited by 1 Publication

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Purity & Quality Control

Batch: S409201 DMSO] 66 mg/mL] false] Water] 66 mg/mL] false] Ethanol] 66 mg/mL] false Purity: 99.89%
99.89

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Biological Activity

Description Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.
In vitro
In vitro

Pramoxine is used primarily in combination with colloidal oatmeal, hydrocortisone, menthol, and petrolatum. [1]
In Vivo
In vivo

Pramoxine (1.7 mM) causes a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride on the guinea-pig ileum. Pramoxine exhibits anesthetic inhibitory potency on the guinea-pig ileum with pKa of 6.4. [2] Pramoxine produces shifts in specific skin temperature at which activation and suppression of both panting and shivering occur in dogs, these changes are interpreted as indicating peripheral mediation in control of thermoregulatory end mechanisms. [3]

Chemical lnformation & Solubility

Molecular Weight 329.86 Formula

C17H27NO3.HCl
CAS No. 637-58-1 SDF Download Pramoxine HCl SDF
Smiles CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 66 mg/mL ( (200.08 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 66 mg/mL

Ethanol : 66 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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