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Sodium benzoate

Name: Sodium benzoate
Brand: Selleck Chemicals
SKU: S3750

Synonyms: Benzoic acid sodium salt

Catalog No.S3750 Purity: 99.37%

Sodium benzoate (Benzoic acid sodium salt) is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions.

Sodium benzoate Chemical Structure

CAS: 532-32-1

Purity & Quality Control

Batch: S375001 Water] 28 mg/mL] false] DMSO] 3 mg/mL] false] Ethanol] Insoluble] false Purity: 99.37%

99.37

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Biological Activity

Description	Sodium benzoate (Benzoic acid sodium salt) is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions.

In vitro
In vitro	Sodium benzoate causes chromosome aberrations in Chinese hamster fibroblast cell line^[2].
Cell Research	Cell lines	Human lymphocyte cell line (ATCC PCS-800-013)
	Concentrations	0.5, 1.0, 1.5, and 2.0 mg/mL
	Incubation Time	24 and 48 hrs
	Method	Human lymphocyte cell line (ATCC PCS-800-013) is cultured in RPMI medium containing 10% fetal bovine serum, antibiotics, and phytohemagglutinin M. The human lymphocyte cultures are incubated in 5% CO2 incubator at 37°C. The concentrations of sodium benzoate are 0.5, 1.0, 1.5, and 2.0 mg/mL and the incubation times for treating lymphocytes are 24 and 48 hrs, respectively, for micronucleus test and chromosome study in this study. For micronucleus test, micronuclei preparation is performed. For chromosome study, standard human lymphocyte culture for chromosome study is performed and stained the chromosomes with Giemsa. Micronuclei and chromosome breakage are observed under microscope.

In Vivo
In vivo	The performance of the NaB(Sodium benzoate)-treated rats is impaired in the elevated plus maze, an indicator of anxiety. Their riding time in fixed and accelerating speed rotarods is decreased, indicating motor impairment^[1].
Animal Research	Animal Models	Sprague-Dawley adult male rats
	Dosages	200mg/kg/day
	Administration	gavage

References

Chemical lnformation & Solubility

Molecular Weight	144.1	Formula	C₇H₅O₂.Na
CAS No.	532-32-1	SDF	Download Sodium benzoate SDF
Smiles	C1=CC=C(C=C1)C(=O)[O-].[Na+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 28 mg/mL

DMSO : 3 mg/mL ( (20.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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