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Succimer

Name: Succimer
Brand: Selleck Chemicals
SKU: S4692

Synonyms: DMSA, meso-2,3-dimercaptosuccinic acid

Catalog No.S4692 Purity: 99.51%

Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.

Succimer Chemical Structure

CAS: 304-55-2

Purity & Quality Control

Batch: S469201 DMSO] 36 mg/mL] false] Ethanol] 3 mg/mL] false] Water] Insoluble] false Purity: 99.51%

99.51

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Biological Activity

Description	Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03653702	Not yet recruiting	Vesico-Ureteral Reflux	Boston Children''s Hospital	October 1 2023	Phase 1
NCT05595863	Not yet recruiting	Brain Glioma	Assiut University	November 2022	--
NCT05593809	Not yet recruiting	Brain Glioma	Assiut University	October 2022	--
NCT04091685	Unknown status	Dimercaptosuccinic Acid SPECT and Planar	Assiut University	September 2019	--
NCT03959163	Recruiting	Pyelonephritis\|Pyelonephritis Acute\|Renal Sclerosis	University of Wisconsin Madison	May 7 2019	Not Applicable
NCT03879005	Unknown status	The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients	Assiut University	April 2019	Not Applicable

Chemical lnformation & Solubility

Molecular Weight	182.22	Formula	C₄H₆O₄S₂
CAS No.	304-55-2	SDF	--
Smiles	C(C(C(=O)O)S)(C(=O)O)S
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 36 mg/mL ( (197.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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