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Sucralfate

Name: Sucralfate
Brand: Selleck Chemicals
SKU: S4670

Synonyms: Sucrose octasulfate-aluminum complex

Catalog No.S4670 Purity: 99%

Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.

Sucralfate Chemical Structure

CAS: 54182-58-0

Purity & Quality Control

Content of Al: 20.5%; Content of S: 10.5%
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Biological Activity

Description	Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.

In vitro
In vitro	Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I^[3]. It protects RGMl cells from acid- and pepsin-induced damage^[4].
Cell Research	Cell lines	RGMl cells
	Concentrations	0.1, 0.3, 1, 3 mg/mL
	Incubation Time	0.5-4 h
	Method	Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO₂, in air for 0.5-4 h. In some cases, cells are treated with 10^-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate.

In Vivo
In vivo	The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region^[2].
Animal Research	Animal Models	C57BL/6J mice
	Dosages	3, 30, or 300 mg/kg
	Administration	by gastric intubation

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04918758	Recruiting	Radiation Proctopathy	Manchester University NHS Foundation Trust\|National Institute for Health Research United Kingdom	July 22 2021	Not Applicable
NCT04327869	Completed	Capsule Endoscopy	Changhai Hospital	November 3 2018	--

References

[4] Furukawa O, et al. J Gastroenterol Hepatol. 1997, 12(5):353-9.

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Chemical lnformation & Solubility

Molecular Weight	2086.74	Formula	C₁₂H₅₄Al₁₆O₇₅S₈
CAS No.	54182-58-0	SDF	Download Sucralfate SDF
Smiles	C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al].[Al].[Al].[Al].[Al].[Al].[Al].[Al]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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