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Dropropizine

Synonyms: UCB-1967,(±)- Dropropizine

Dropropizine (UCB-1967,(±)- Dropropizine) is a racemic non-opiate antitussive agent, it is used as a cough suppressant.

Dropropizine Chemical Structure

Dropropizine Chemical Structure

CAS: 17692-31-8

Purity & Quality Control

Batch: S413801 DMSO] 47 mg/mL] false] Ethanol] 47 mg/mL] false] Water] 11 mg/mL] false Purity: 99.41%
99.41

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Biological Activity

Description Dropropizine (UCB-1967,(±)- Dropropizine) is a racemic non-opiate antitussive agent, it is used as a cough suppressant.
In vitro
In vitro

Dropropizine shows neither mutagenic nor clastogenic effects in Chinese hamster V79 and human EUE cells, while Lithium carbonicum manifestes a weak and mazindol a medium genotoxic response which is in both cases reduce in the presence of microsomal fraction S9. [1]
In Vivo
In vivo

Dropropizine exhibits antitussive activity in cats noticeably lower than Pinacidil and Codeine. [2] Dropropizine (100 mg/kg, b.w., intraperitoneally) has similar antitussive activity as that of EEPF (200 mg/kg, b.w., orally). [3] Dropropizine exhibits antitussive activity of 28.3% in mechanically induced cough in nonanaesthetized cats, comparable to prenoxdiazine (24.7%).[4] Dropropizine (dropro–dose 100 mg/kg b.w.) exhibits comparable cough-suppressing effect of mucilage from S. althaeae. Dropropizine (dropro–dose 100 mg/kg b.w.) exhibits antitussive activity less than E. officinalis on the mechanically induced cough reflex under experimental conditions. [5]

Chemical lnformation & Solubility

Molecular Weight 236.31 Formula

C13H20N2O2
CAS No. 17692-31-8 SDF Download Dropropizine SDF
Smiles C1CN(CCN1CC(CO)O)C2=CC=CC=C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 47 mg/mL ( (198.89 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 47 mg/mL

Water : 11 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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