Catalog No. |
Product Name |
Information |
S3611 |
(+)-Fangchinoline |
Fangchinoline ((+)-Limacine, Tetrandrine B, Hanfangichin B) is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity.
|
S5934 |
(-)-Fenchone |
Fenchone is a constituent of absinthe and the essential oil of fennel. It is used as a flavor in foods and in perfumery. |
S6107 |
1-Furfurylpyrrole |
1-Furfurylpyrrole (N-Furfurylpyrrole) is a potential contributor of flavor and aroma to popcorn. |
S7153 |
10058-F4 |
10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 promotes a caspase-3-dependent apoptosis and modulates autophagy. |
S6320 |
2,5-Furandicarboxylic acid |
2,5-Furandicarboxylic acid (Dehydromucic acid) is a normal urinary metabolite in humans and an important renewable building block because of its potential as a substitute for a variety of petrochemicals, such as terephthalic acid and adipic acid. |
S4864 |
2-Furoic acid |
2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent. |
S6848 |
3'-Fluoro-3'-deoxythymidine (Alovudine) |
3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
S6097 |
3-Furoic acid |
3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. |
E0070 |
4F 4PP oxalate |
4F 4PP oxalate is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 5.3 nM), which is selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM). |
S0550 |
5'-Fluoroindirubinoxime |
5'-Fluoroindirubinoxime (5’-FIO, compound 13), an indirubin derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM. |
S9873 |
5-Fluoroorotic acid |
5-Fluoroorotic acid (5-FOA, 5-Fluoroorotate, NSC 31712) is a selective agent in yeast molecular genetics. 5-Fluoroorotic acid possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects. |
S1209 |
5-FU (5-Fluorouracil) |
5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
S0302 |
F1063-0967 |
F1063-0967 is an inhibitor of Dual-specificity phosphatase 26 (DUSP26) with IC50 of 11.62 μM. |
S2474 |
Fabomotizole hydrochloride |
Fabomotizole hydrochloride (Fabomotizole, CM346, CM346, Afobazol, Afobazole) exhibits anxiolytic and neuroprotective properties. Fabomotizole hydrochloride is a potent sigma1-receptor agonist with IC50 of 7.1 µM and Ki of 5.9 µM.
|
S7371 |
Fadraciclib (CYC065) |
Fadraciclib (CYC065) is a novel, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50 of 5 nM and 26 nM, respectively. |
S9519 |
Fadrozole (CGS16949A) |
Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes. |
E3733 |
Faeces Trogopterori Extract |
Faeces Trogopterori Extract is derived from the faeces of the complex-toothed flying squirrel Trogopterus xanthipes Milne-Edwards. |
S3292 |
Falcarindiol |
Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules. |
E2399 |
Falnidamol |
Falnidamol (BIBX1382) is a selective inhibitor of epidermal growth factor receptor (EGFR), exerting anti-cancer role in human head and neck squamous cell carcinomas both in vitro and in vivo through suppressing mitogen-activated protein kinases (MAPKs) signaling. |
S2467 |
Famciclovir |
Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. |
S2078 |
Famotidine |
Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions. |
S4327 |
Famprofazone |
Famprofazone (Geodowin, FA, Famprofazonum) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series. Famprofazone is an analgesic used for fever and pain relief. |
S3606 |
Fangchinoline |
Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
|
S9285 |
Fargesin |
Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
D4015 |
Farletuzumab-MMAE |
Farletuzumab-MMAE is an antibody-drug conjugate (ADC) composed of humanized anti-human folate receptor-alpha (FRα) and the cytotoxic agent monomethyl auristatin (MMAE) via a MC-Vc linker. It has a potent antitumor activity. |
S4941 |
Farnesol |
Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects. |
S6150 |
Farnesyl Acetate (mixture of isomers) |
Farnesyl Acetate is a flavouring compound identified in foods such as blueberries. |
S4847 |
Faropenem Sodium |
Faropenem sodium is an orally active beta-lactam antibiotic that has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia. |
S9552 |
Farrerol |
Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects. |
S9721 |
Farudodstat |
Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors. |
S2637 |
Fasiglifam(TAK-875) Hemihydrate |
Fasiglifam(TAK-875) Hemihydrate is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid. |
S6248 |
Fasnall |
Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity. |
E1773 |
Fasoracetam (NS 105) |
Fasoracetam (NS 105) is a metabotropic glutamate receptor activator with a potential to treat vascular dementia. |
E2913 |
Fast Green FCF |
Fast Green FCF (FD&C Green No. 3; Food green 3; C.I. 42053) is a sea green triarylmethane food dye. It is a dye used to stain proteins for IEF (isoelectric focusing) and SDS-PAGE. When bound to proteins, Fast Green FCF fluoresces near infrared (absorption maximum: 624 nm). Fast Green FCF staining is linear over a wider range of protein concentrations compared to Brilliant Blue R. |
S1573 |
Fasudil HCl |
Fasudil HCl, a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker. |
E2950 |
Fat Emulsion(20%) |
Fat Emulsion(20%)is a safe fat emulsion that can be used as a nutritional supplement. Fat Emulsion(20%)inhibits the opening of the mitochondrial permeability transition pore and effectively protecting the heart from ischaemia-reperfusion injury. It has some potential to modulate the innate immune response. |
S9785 |
Fatostatin |
Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.
|
S8284 |
Fatostatin HBr |
Fatostatin HBr is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2. |
S7975 |
Favipiravir (T-705) |
Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
|
S6291 |
FB23 |
FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. |
S8837 |
FB23-2 |
FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N6-methyladenosine (m6A) demethylase activity with IC50 of 2.6 μM. |
E2846 |
FBPase-1 inhibitor-1 |
FBPase-1 inhibitor-1, an allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1), exhibits similar potency (IC50 = 3.4 μM using MG; = 4.0 μM in the coupled format) in these two distinct assays of FBPase-1 activity. |
S8276 |
FCCP |
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. |
L3800 |
FDA-approved & Passed Phase I Drug Library |
A unique collection of 3621 drugs that are marketed around the world or have passed clinical phase 1 and can be used for high throughput screening (HTS) and high content screening (HCS). |
L8000 |
FDA-approved Anticancer Drug Library |
A unique collection of 1746 approved drugs with potential anticancer activity used for high throughput screening(HTS) and high content screening(HCS). |
L1300 |
FDA-approved Drug Library |
A unique collection of 3109 approved drugs and API included in pharmacopoeia for high throughput screening (HTS) and high content screening (HCS). |
S9689 |
FDI-6 |
FDI-6 (NCGC00099374) is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) with IC50 of 22.5 μM. |
S8795 |
FDL169 |
FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
S5092 |
Febantel |
Febantel (Rintal, Combotel, Oratel, Bay Vh 5757, Negabot Plus) is a prodrug that is metabolized to fenbendazole and oxfendazole, which are undoubtedly the active parasiticides. |
S1547 |
Febuxostat |
Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM. |
S2736 |
Fedratinib (TG101348) |
Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2. |
S1330 |
Felbamate |
Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist. |
S1885 |
Felodipine |
Felodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. |
P1047 |
Felypressin Acetate |
Felypressin-Acetate is a non-catecholamine vasoconstrictor that is chemically associated to vasopressin, the posterior pituitary hormone. |
S3397 |
FEN1-IN-4 |
FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ. |
S5517 |
Fenamic acid |
Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. |
S2468 |
Fenbendazole |
Fenbendazole(Fenbendazol,Phenbendasol) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/mL. |
S4526 |
Fenbufen |
Fenbufen (Lederfen, CL-82204) is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug. |
S5379 |
Fenchyl Alcohol |
Fenchyl Alcohol is used as a flavoring agent to provide a pine, herbal, lemon, or floral taste to food and drink. |
S5279 |
Fendiline hydrochloride |
Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. |
S8421 |
Fenebrutinib (GDC-0853) |
Fenebrutinib (GDC-0853) is a potent, selective, and non-covalent bruton's tyrosine kinase (BTK) inhibitor with an Ki value of 0.91 nM for Btk with >100-fold selectivity over 3 off-targets (Bmx :153-fold, Fgr: 168-fold, Src:131-fold).
|
S5702 |
Fenipentol |
Fenipentol (1-phenylpentan-1-ol, 1-Phenyl-1-pentanol, 1-Phenylpentanol) is a member of benzenes and stimulates plasma secretion & exocrine pancreatic secretion. |
S1794 |
Fenofibrate |
Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy. |
S4527 |
Fenofibric acid |
Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides. |
S2089 |
Fenoldopam |
Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA . |
S4618 |
Fenoldopam mesylate |
Fenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
S1823 |
Fenoprofen Calcium |
Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent. |
S3027 |
Fenoprofen calcium hydrate |
Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID). |
S5769 |
Fenoterol |
Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity. |
S5768 |
Fenoterol hydrobromide |
Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity. |
S5233 |
Fenretinide |
Fenretinide is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death. |
S4090 |
Fenspiride HCl |
Fenspiride(Decaspiride) is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi. |
S2031 |
Fenticonazole Nitrate |
Fenticonazole Nitrate(Lomexin,REC 15-1476,Falvin) is an azole antifungal agent. |
E3297 |
Fenugreek Seed Extract |
Fenugreek Seed Extract is extracted from the seeds of Trigonella foenum-graecum, which acts as an antibacterial and anticancer agent. |
S7243 |
Fer-1 (Ferrostatin-1) |
Fer-1 (Ferrostatin-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
E3166 |
Fermented Blank Bean Extract |
Fermented Blank Bean Extract is extracted from the fermented Phaseolus vulgaris L., and aids in protection of the human digestive tract, mainly the colon. |
E3137 |
Fermented Soybean Extract |
Fermented Soybean Extract is obtained from Fermented soybean, which shows high antioxidant activity. |
L6400 |
Ferroptosis Compound Library |
A unique collection of 730 compounds used for exploring the mechanism of ferroptosis which is an iron-dependent form of non-apoptotic cell death. |
S6449 |
Ferrous Bisglycinate |
Ferrous bisglycinate (Iron glycinate) is a chelate that is used as a source of dietary iron. It acts as both a chelate and a nutritionally functional.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! |
S6406 |
Ferrous fumarate |
Ferrous fumarate (Iron(II)) is the fumarate salt form of the mineral iron and is used in treatment of iron deficiency anemia. |
S9221 |
Ferulaldehyde |
Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora. |
S2300 |
Ferulic Acid |
Ferulic Acid (Fumalic) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong. Ferulic acid is a novel fibroblast growth factor receptor (FGFR) inhibitor with IC50s of 3.78 μM and 12.5 μM for FGFR1 and FGFR2, respectively. |
S5451 |
Ferulic acid methyl ester |
Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer. |
E3766 |
Feverfew Extract |
Feverfew Extract is obtained from Tanacetum parthenium L., which is a herbal remedy used for preventing attacks of migraine. |
S6413 |
fexaramine |
Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. |
S2600 |
Fexinidazole |
Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness). |
S3208 |
Fexofenadine HCl |
Fexofenadine (MDL 16455A) inhibits histamine H1 receptor with IC50 of 246 nM. |
E0109 |
Fezolinetant |
Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle. |
S8899 |
FF-10101 |
FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively. |
S7979 |
FG-2216 |
FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.
|
E0621 |
FGFR1/DDR2 inhibitor 1 |
FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2). |
S7450 |
FH1 |
FH1 is a small molecule, which promotes differentiation of iPS-derived hepatocytes. |
E1178 |
FHD-286 |
FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia. |
E1711 |
FHT-1015 |
FHT-1015 is a potent, small-molecule, allosteric inhibitor of SMARCA4/SMARCA2 ATPase with IC50 values ≤10 nM. FHT-1205 decreases PD1+TIM3+ cells and cytokine expression in vivo. |
E1709 |
Fialuridine |
Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex. |
A2661 |
Ficlatuzumab (Anti-HGF / SF) |
Ficlatuzumab (Anti-HGF / SF) is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). It inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion and can be used to treat head and neck squamous cell carcinoma (HNSCC). MW :150 KD. |
E4035 |
Ficoll(R) 400 |
Ficoll(R) 400 (sucrose-epichlorohydrin copolymer) is a macromolecular crowder that plays a pivotal role in promoting liquid-liquid phase separation (LLPS) of proteins. It is currently utilized in the isolation of serum and peripheral blood mononuclear cells (PBMC) from the whole blood of Parkinson's disease (PD) patients. |
E3724 |
Ficus carica Extract |
Ficus Carica Extract is obtained from Ficus carica Linn. (Moraceae), which has been used in traditional medicine for a wide range of ailments related to digestive, endocrine, reproductive, and respiratory systems. |
E3735 |
Ficus hirta Vahl Extract |
Ficus Hirta Vahl Extract is derived from Ficus hirta Vahl. (Wuzhimaotao), which possesses hepatoprotective, antibacterial, and anti-inflammatory bioactivities and improves memory function of AD mice. |
S9682 |
FICZ |
FICZ (6-Formylindolo[3,2-b]carbazole) is a potent agonist of aryl hydrocarbon receptor (AhR) that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. |
E0081 |
FIDAS-3 |
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A. |
S4227 |
Fidaxomicin |
Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. |
S7715 |
FIIN-3 |
FIIN-3 is an irreversible inhibitor of FGFR with an IC50 of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. |
S7354 |
Filanesib hydrochloride |
Filanesib (ARRY-520) hydrochloride is a kinesin spindle protein (KSP) inhibitor that blocks the separation of centrosomes and assembly of spindles in the early stage of cell mitosis, and cell proliferation. |
S0843 |
Filastatin |
Filastatin, a long-lasting inhibitor of Candida albicans filamentation, inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. |
S7605 |
Filgotinib (GLPG0634) |
Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.
|
S4975 |
Fimasartan |
Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure. |
S2759 |
Fimepinostat (CUDC-907) |
CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1. |
S1197 |
Finasteride |
Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). |
E3366 |
Fineleaf Schizonepeta Herb Extract |
Fineleaf Schizonepeta Herb Extract is extracted from the leaves of Schizonepeta, which is used as a traditional medicine with antipyretic, anti-inflammatory, analgesic, and hemostatic effects. |
S9702 |
Finerenone |
Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease. |
S5950 |
Fingolimod (FTY-720) |
Fingolimod (FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. |
S5002 |
Fingolimod (FTY720) HCl |
Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation. |
E1244 |
FINO2 |
FINO2 is a potent ferroptosis inducer which inhibits GPX4 activity. FINO2 causes widespread lipid peroxidation. |
S6478 |
Fipexide hydrochloride |
Fipexide (hydrochloride) is a psychoactive drug of the piperazine class. |
S7321 |
FIPI |
FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively. |
E0500 |
Firocoxib (ML 1785713) |
Firocoxib (ML 1785713) is a cyclooxygenase (COX)-2 inhibitor and a nonsteroidal anti-inflammatory drug. In vitro firocoxib inhibits COX-1 and COX-2 with an IC50 of 7.5 mM and 0.13 mM respectively in feline blood. |
S8893 |
Firsocostat (GS-0976, ND-630) |
Firsocostat (GS-0976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively. |
S8503 |
Fisogatinib (BLU-554) |
Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM. |
E2695 |
FITC-Dextran (MW 10000) |
FITC-Dextran(MW 10000) are polysaccharides comprised of varying lengths of branched glucose molecules and can be used to determine solute, ion and protein permeability of the blood-brain barrier (BBB) based on the size of the dextran used. |
S2595 |
FK-3311 |
FK-3311 (COX-2 Inhibitor V) is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2. |
S0535 |
FK962 |
FK962, a derivative of FK960 with putative anti-dementia properties, significantly enhances high K+-evoked somatostatin release from rat hippocampal slices at 1-1000 nM, also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons. |
S1027 |
FL-411 |
FL-411 (BRD4-IN-1) is a potent and selective inhibitor of Bromodomain-containing protein 4 (BRD4) with IC50 of 0.43 μM for BRD4(1). FL-411 induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction. |
E1713 |
FL118 |
FL118(10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin analog, is a potent and orally active inhibitor of Survivin. FL118 also selectively and independently inhibits three additional cancer-associated survival genes Mcl-1, XIAP, and cIAP2 in a p53 status-independent manner. FL118 displays potent antitumor activity and can be used in cancer research. |
E3094 |
Flatstem Milkvetch Seed Extract |
Flatstem Milkvetch Seed Extract is obtained from the dried ripe seed of Flatstem Milkvetch, benefits the liver and the kidney, arrests seminal discharge, restrains urination and improves eyesight. |
S3679 |
Flavanone |
Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties. |
E0705 |
Flavin Adenine Dinucleotide Disodium |
Flavin Adenine Dinucleotide Disodium is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. |
S5600 |
Flavokawain A |
Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells. |
S3967 |
Flavone |
Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. |
L7700 |
Flavonoid Compound Library |
A unique collection of 260 flavonoid compounds used for high throughput screening(HTS) and high content screening(HCS). |
S1230 |
Flavopiridol (Alvocidib) |
Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2. |
S2679 |
Flavopiridol (Alvocidib) HCl |
Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2. |
S4027 |
Flavoxate HCl |
Flavoxate (NSC-114649) is a muscarinic AChR antagonist with IC50 of 12.2 μM. |
E3796 |
Flaxseed Extract |
Flaxseed Extract is drawed from Linum usitatissimum, which can regulate the growth of MCF-7 cells and induce apoptosis. |
E0528 |
Flecainide |
Flecainide is a common medication used to help restore and maintain sinus rhythm in patients with atrial fibrillation. |
S2469 |
Fleroxacin |
Fleroxacin (Ro 23-6240,AM-833,Quinodis, Megalocin) is a new broad-spectrum fluoroquinolone. |
S7399 |
FLI-06 |
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
S3716 |
Flibanserin |
Flibanserin (BIMT-17, BIMT-17-BS) is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors. |
S7259 |
FLLL32 |
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.
|
S4249 |
Flopropione |
Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist. |
S4201 |
Florfenicol |
Florfenicol (SCH-25298,(-)-Florfenicol) is a fluorinated synthetic analog of thiamphenicol with broad-spectrum, primarily bacteriostatic activity. |
E3787 |
Flos Inulae Extract |
Flos Inulae Extract is drawed from Flos Inulae, which can be applied to antimutation, antityrosinase and anti-inflammation. |
S1299 |
Floxuridine (FUDR) |
Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV. |
E2387 |
FLT3-IN-2 |
FLT3-IN-2 is a FLT3 inhibitor with IC50 of < 1 μM. |
S1837 |
Flubendazole |
Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection. |
S4850 |
Flucloxacillin sodium |
Flucloxacillin sodium (Floxacillin sodium) is the sodium salt of flucloxacillin, a penicillin antibiotic used to treat bacterial infections. |
S1331 |
Fluconazole |
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. |
S1666 |
Flucytosine (5-Fluorocytosine) |
Flucytosine (5-Fluorocytosine) is an antifungal drug with IC50 of 0.93 μM in C. albicans. |
S1491 |
Fludarabine |
Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. |
S1229 |
Fludarabine Phosphate |
Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
S3659 |
Fludrocortisone acetate |
Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. |
S4268 |
Flufenamic acid |
Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. |
E0514 |
Flugestone 17-acetate |
Flugestone 17-acetate (Flurogestone acetate) is a corticosteroid hormone. |
S9973 |
Flumatinib (HH-GV-678) |
Flumatinib (HH-GV-678) is a novel inhibitor of Bcr-Abl with IC50 values of 1.2 nM, 307.6 nM and 665.5 nM for c-Abl, PDGFRβand c-Kit, respectively.
|
S1332 |
Flumazenil |
Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
S3181 |
Flumequine |
Flumequine(R-802) is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
S4088 |
Flumethasone |
Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions. |
S2030 |
Flunarizine 2HCl |
Flunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM. |
S2108 |
Flunixin Meglumin |
Flunixin Meglumin(Banamine) is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity. |
S2470 |
Fluocinolone Acetonide |
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. |
S2608 |
Fluocinonide |
Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. |
S5488 |
Fluorescein |
Fluorescein (Solvent Yellow 94, Resorcinolphthalein, Yellow fluorescein) is a manufactured organic compound and dye. |
S6928 |
Fluorescein-5-isothiocyanate (FITC) |
Fluorescein-5-isothiocyanate (FITC, Fluorescein isothiocyanate isomer I, 5-FITC) is a fluorescent probe capable of being conjugated to tissue and proteins. |
E4034 |
Fluorescent Brightener 28 |
Fluorescent Brightener 28 (Tinopal UNPA-GX) is a viability stain used for identification of structure chitin and fungi. It is also used as a fluorescent brightening agent for cellulose and polyamide fabrics, paper and in detergents and soaps. |
E1620 |
Fluorofurimazine |
Fluorofurimazine is a novel furimazine analogue, with increased aqueous solubility enabling higher signal emission than furimazine for bioluminescence imaging. Fluorofurimazine enables higher substrate loading and improved optical imaging sensitivity in in-vivo. |
S5486 |
Fluorometholone |
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye. |
S4228 |
Fluorometholone Acetate |
Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. |
S5421 |
Fluoroquinolonic Acid |
Fluoroquinolonic Acid (Ciprofloxacin Impurity A, Q-Acid) is an antibiotic and antimicrobial agent. |
S1333 |
Fluoxetine HCl |
Fluoxetine HCl is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression. |
S4569 |
Fluphenazine dihydrochloride |
Fluphenazine dihydrochloride (Prolixin) is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor. |
S1334 |
Flupirtine maleate |
Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. |
S6470 |
Fluralaner |
Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally.Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls) |
S1679 |
Flurbiprofen |
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). |
S6457 |
Flurbiprofen Axetil |
Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase. |
E1410 |
Fluspirilene |
Fluspirilene(R 6218; Redeptin) is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM in cell-free assays. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia. |
S1908 |
Flutamide |
Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer. |
S6487 |
fluticasone furoate |
Fluticasone furoate (GW685698) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. |
S1992 |
Fluticasone propionate |
Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis. |
S1909 |
Fluvastatin Sodium |
Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay. |
S1336 |
Fluvoxamine (DU-23000) maleate |
Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder. |
S9712 |
Fluzoparib (SHR-3162) |
Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity, with an IC50 of 1.46±0.72 nM for PARP1. |
S8541 |
FM-381 |
FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively. |
E1712 |
FM19G11 |
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. |
S0091 |
Fmoc-Val-Ala-PAB |
Fmoc-Val-Ala-PAB (Fmoc-Val-Ala-PAB-OH) is a useful and cleavalbe linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. |
S6688 |
Fmoc-Val-Cit-PAB |
Fmoc-Val-Cit-PAB (Fmoc-Val-Cit-PAB-OH) is a cleavable linker for antibody-drug conjugates (ADC). |
E2658 |
FN-1501 |
FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. |
E3768 |
Foeniculum Vulgare Extract |
Foeniculum Vulgare Extract is obtained from Foeniculum vulgare (Apiaceae), which is traditionally suggested for the fertility improvement in Iranian lore due to its antioxidant and phytoestrogen compounds. |
S4605 |
Folic acid |
Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
S5790 |
Folinic acid (Leucovorin) |
Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared. |
S1717 |
Fomepizole |
Fomepizole (4-methylpyrazole, Antizol, Antizol-Vet) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. |
S3736 |
Fondaparinux Sodium (Org 31540) |
Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa. |
S6159 |
Food Yellow 3 |
Food Yellow 3 (Sunset yellow) is an azo dye that is useful in fermented foods which must be heat treated. |
S5306 |
Forchlorfenuron (CPPU) |
Forchlorfenuron (CPPU) is a synthetic cytokinin that inhibits septins and exhibits anti-parasitic, anticancer, and anti-angiogenic activities. |
S1111 |
Foretinib |
Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2. |
E2922 |
Formamide |
Formamide (Methanamide; Formimidic acid) is a clear liquid amide derived from formic acid. It allows for the denaturation and renaturation of nucleic acids at room temperature. Formamide-induced DNA denaturation when combined with detection of denatured DNA with a monoclonal antibody (MAb) makes it possible to specifically identify the apoptotic cells. |
E2995 |
Formamide deionized |
Formamide deionized(Methanamide, Formimidic acid) is a clear liquid amide derived from formic acid that serves as an essential solvent for catalytic hydrogenation reactions and acts as a reagent in the creation of diverse organometallic compounds. |
S5382 |
Formate |
Formate is the anion derived from formic acid, an important intermediate in chemical synthesis and occurs naturally, most notably in some ants.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
S2208 |
Formestane |
Formestane (CGP-32349, NSC 282175) is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
S2299 |
Formononetin |
Formononetin (Formononetol, Biochanin B) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone. |
S2020 |
Formoterol Hemifumarate |
Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD). |
S2449 |
Forskolin (Colforsin) |
Forskolin (Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy. |
E3415 |
Forsythia suspensa Extract |
Forsythia suspensa Extract is extracted from Forsythia suspensa. |
S3926 |
Forsythin |
Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties. |
S9184 |
Forsythoside B |
Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB. |
S6581 |
Fosamprenavir calcium salt |
Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections. |
S3038 |
Fosaprepitant dimeglumine salt |
Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. |
S7204 |
Fosbretabulin (Combretastatin A4 Phosphate) Disodium |
Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3. |
S3076 |
Foscarnet Sodium |
Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
E0465 |
Fosciclopirox |
Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2. It is used in the treatment of urothelial cancer and a number of solid and hematologic malignancies. |
S6467 |
Fosfluconazole |
Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. |
S3710 |
Fosfomycin calcium |
Fosfomycin (phosphomycin, phosphonomycin) is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. It enters the bacterial cell through the glycerophosphate transporter. |
S5048 |
Fosfomycin Disodium |
Fosfomycin (Phosphonemycin) is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis. |
S5729 |
Fosfosal |
Fosfosal (2-phosphonoxy benzoic acid) is a non-acetylated salicylic acid derivative, with analgesic and anti-inflammatory activity, but without effects on PG biosynthesis in vitro. |
S2095 |
Fosinopril Sodium |
Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure. |
S6482 |
Fosphenytoin (disodium) |
Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. |
S2625 |
Fostamatinib (R788) |
Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. |
S2206 |
Fostamatinib (R788) disodium |
Fostamatinib disodium (R788, Tamatinib Fosdium), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. |
S4944 |
Fostamatinib disodium hexahydrate |
Fostamatinib (R788) disodium (Tamatinib Fosdium) hexahydrate, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay. |
S7220 |
Fostemsavir |
Fostemsavir (BMS-663068, Rukobia), the phosphonooxymethyl prodrug of BMS626529, is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of < 10 nM. |
S6961 |
Foxy-5 |
Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer. |
S3511 |
FOY251 |
FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection. |
S7451 |
FPH1 |
FPH1 is a small molecule, which promotes expansion of iPS-derived hepatocytes. |
S7452 |
FPH2 (BRD-9424) |
FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.
|
S0759 |
FPL 62064 |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity. |
S8185 |
FPS-ZM1 |
FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE. |
E1275 |
FR054 |
FR054 is a novel inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3 with a remarkable anti-breast cancer effect. |
L1600 |
Fragment Library |
A unique collection of 1015 Fragment compounds for Fragment-Based Drug Discovery (FBDD). |
E0511 |
Framycetin sulphate |
Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM, and competes for specific divalent metal ion binding sites in RNase P RNA, also inhibits hammerhead ribozyme with a Ki of 13.5 μM. |
S9503 |
Fraxetin |
Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein. |
S9296 |
Fraxin |
Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis. |
S2418 |
Frentizole |
Frentizole (Frentizol) is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus. |
E3578 |
Fringed pink Extract |
Fringed Pink Extract is extracted from Dianthus superbus, which has anti-inflammatory activity. |
E3099 |
Fritillaria Cirrhosa Seed Extract |
Fritillaria Cirrhosa Seed Extract is extracted from the seeds of Fritillaria Cirrhosa, which is famous for its antitussive, expectorant, anti-asthma and anti-inflammatory properties, and is widely used to treat respiratory diseases. |
E3098 |
Fritillariae Cirrhosae Bulbus Extract |
Fritillariae Cirrhosae Bulbus Extract is obtained from Fritillariae cirrhosae, mediates apoptosis through a STAT1 and STAT4-mediated co-regulatory network, which may be the key novel mechanism for its antitumor activity. |
E3867 |
Fritillariae Thunbergii Bulbus Extract |
Fritillariae Thunbergii Bulbus Extract is extracted from Fritillariae thunbergii bulbus, which is used to treat symptoms of cough and airway congestion in the chest due to pathological colds and damp phlegm. |
S5848 |
Frovatriptan Succinate |
Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors. |
S5176 |
Fructose |
Fructose (D-(-)-Fructose, Fruit sugar, levulose, fructosteril, D-fructofuranose, D-arabino-hexulose) is a simple ketonic monosaccharide found in many plants. |
E3847 |
Fructus Akebiae Extract |
Fructus Akebiae Extract is extracted from Fructus akebiae, which is used for the treatment of mental disorders. |
E3006 |
Fructus Anisi Stellati Extract |
Fructus Anisi Stellati Extract is extracted from the fruit of Illicium verum, which involves in signalling pathways that target cancer cell apoptosis, proliferation, and tumour metastasis in Gastric cancer cells. |
E3474 |
Fructus Chebulae Extract |
Fructus Chebulae Extract is extracted from the mature fruit of Terminalia chebula Retz., which can rescue neuronal cell death against ischemia-related damage. |
E3721 |
Fructus mume Extract |
Fructus mume Extract is obtained from the processed fruit of Fructus mume Sieb. et Zucc., which effectively improves cognitive impairment in familial Alzheimer's disease, scopolamine-induced memory impairment, and chronic cerebral hypoperfusion-induced cognitive impairment. |
E3393 |
Fructus azedarach Extract |
Fructus azedarach Extract is extracted from Fructus azedarach. |
S5667 |
Fruquintinib |
Fruquintinib is a small molecule inhibitor with strong potency and high selectivity against VEGFR family. It inhibits VEGFR 1, 2, 3, with IC50 values of 33 nM, 35 nM and 0.5 nM, respectively and shows only weak inhibition of RET, FGFR-1 and c-kit kinases. |
E1574 |
FSEN1 |
FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. It triggers iron death in cancer cells by inhibiting FSP1 and can be used in research of cancer. |
S8428 |
FSL-1 |
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection. |
S9915 |
FSLLRY-NH2 TFA |
FSLLRY-NH2 TFA (FSY-NH2) is a selective protease-activated receptor 2 (PAR2) inhibitor with an ic50 of 50 µM in PAR2-KNRK cells.
|
S6666 |
FT113 |
FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM. |
S6464 |
Ftaxilide |
Ftaxilide is a novel antituberculosis agent. |
S7465 |
FTI 277 HCl |
FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia. |
E0365 |
Fucoidan |
Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
|
E3488 |
Fucus vesiculosis Extract |
Fucus Vesiculosis Extract is extrcated from Fucus vesiculosus, which has antifungal properties. |
S2129 |
Fudosteine |
Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases. |
S0042 |
Fulacimstat |
Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively. |
S1191 |
Fulvestrant |
Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity. |
S7784 |
Fumagillin |
Fumagillin(Amebacilin,NSC9168) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
|
S4952 |
Fumaric acid |
Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle. |
S3709 |
Furagin |
Furagin (NF-416, F-35, Akritoin, Furazidin, Furazidine) is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin with antimicrobial activities. |
S4203 |
Furaltadone HCl |
Furaltadone HCl(Altafur hydrochloride) is an antibacterial and has distinct curative effect in the treatment of coccidiosis. |
S4528 |
Furazolidone |
Furazolidone(Furoxone) is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria. |
S6211 |
Furfural |
Furfural is one of the key chemicals produced in the so-called lignocellulosic biorefineries and produced from renewable agricultural sources such as food crop residues and wood wastes.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
S5831 |
Furfuryl acetate |
Furfuryl acetate (Furan-2-ylmethyl, 2-Furanmethanol, 2-Acetoxymethylfuran) is widely used as a flavoring agent in food and bakery. |
S1603 |
Furosemide |
Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema. |
S5194 |
Furosemide sodium |
Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor. |
S6614 |
Fursultiamine |
Fursultiamine (Thiamine tetrahydrofurfuryl disulfide) is a nutritional supplement and vitamin B1 derivative, with potential antineoplastic activity. |
S4663 |
Fusidate Sodium |
Fusidate Sodium (Fucidin, SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections. |
S3971 |
Fusidine |
Fusidine (Fusidic Acid), isolated from Fusidium coccineum, is a steroidal antibiotic that inhibits protein synthesis. |
S8848 |
Futibatinib (TAS-120) |
Futibatinib (TAS-120) is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 1.8 nM, 1.4 nM, 1.6 nM and 3.7 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. |
S8591 |
FX1 |
FX1 is a selective BCL6 BTB inhibitor with an IC50 value of 35 μM in reporter assays. FX1 shows great selectivity against a panel of 50 different kinases. 10 μM FX1 fails to significantly inhibit of any of these kinases. FX1 induces apoptosis. |
S8928 |
FX11 |
FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells. |