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Catalog No. Product Name Information
E2862 (+/-)-Naringenin (±)-Naringenin, a natural flavonoid present in citrus fruits, induces apoptosis and cytotoxicity in cancer cells.
E4175 (±)-Naringenin (±)-Naringenin is a naturally occurring flavonoid. (±)-Naringenin displays a vasorelaxant effect on endothelium-denuded vessels via activating BKCa channels in myocytes.
S9507 (−)-Norepinephrine (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
S9342 1,4-Naphthoquinone 1,4-Naphthoquinone (α-Naphthoquinone, para-naphthoquinone, P-Naphthoquinone), found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide.
S9362 1-Naphthaleneacetic acid 1-Naphthaleneacetic acid (α-Naphthaleneacetic acid) is a synthetic plant hormone in the auxin family.
S4804 1-Naphthyl acetate 1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.
S5441 1-Naphthyl phosphate potassium salt 1-Naphthyl phosphate potassium salt (α-Naphthyl acid phosphate monopotassium salt) is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
E2202 1-Naphthyl PP1 hydrochloride 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases, inhibits v-Src, c-Fyn, c-Abl, CDK2 and CAMKII with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.
S2642 1-Naphthyl PP1(1-NA-PP1) 1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
S6383 1-NM-PP1 1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of Src family kinases with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. 1-NM-PP1 also inhibits CDK2-as1, CAMKII-as1 and c-Abl-as2 with IC50 of 5.0 nM, 8.0 nM and 120 nM, respectively.
S6035 2-Naphthol 2-Naphthol (2-Hydroxynaphthalene, 2-Naphthalenol, beta-Naphthol, Naphth-2-ol, β-naphthol), a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds.
S8914 2-NBDG 2-NBDG, a fluorescent deoxyglucose derivative, is a a marker for detecting glucose uptake and an indicaotr of cell viability.
S9263 3-n-Butylphathlide 3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.
S6345 3-Nitro-L-tyrosine 3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. 3-Nitro-L-tyrosine inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events.
S3652 3-Nitropropionic acid (3-NP) 3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.
S6196 4-Nitrophenol 4-Nitrophenol (p-nitrophenol, 4-hydroxynitrobenzene) is a phenolic compound that can be used as a pH indicator and an intermediate in the synthesis of paracetamol.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
E4014 4-Nitrophenyl alpha-D-glucopyranoside 4-Nitrophenyl alpha-D-glucopyranoside is a chromogenic substrate in the α-glucosidase inhibition assay.
E4033 4-Nitrophenyl beta-D-glucopyranoside 4-Nitrophenyl beta-D-glucopyranoside is a chromogenic β-D-glucosidase substrate, producing a yellow solution upon cleavage. It is degraded by hydrolysis of enzyme β-glucosidase and quantified by colorimetric detection at 405 nm as a measure of β-glucosidase activity.
E2965 4-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranoside 4-Nitrophenyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a useful substrate for rapid colorimetric assay of N-acetyl-b-glucosaminidase activity in human urine. Chromogenic β-Glucosaminidase substrate yielding a yellow solution upon cleavage, employed particularly in yeasts and molds.
E0155 4-Nitroquinoline 1-oxide

4-Nitroquinoline 1-oxide (4-Nitroquinoline-N-oxide, 4-NQO, 4NQO, 4Nqo, NQO, NQNO) is a highly carcinogenic model chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts.
S6347 5'-N-Ethylcarboxamidoadenosine (NECA) 5'-N-Ethylcarboxamidoadenosine (NECA, 5'-(N-Ethylcarboxamido)adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. 5'-N-Ethylcarboxamidoadenosine acts via multiple mechanisms including: reducing diabetes-induced oxidative stress, inhibiting gene expression of IL-18, TNF-α and ICAM-1 (intercellular adhesion molecule 1 (CD54)), and blocking activation of the JNK-MAPK pathway.
E4003 N,N'-Methylenebisacrylamide N,N'-Methylenebisacrylamide(Methylenebisacrylamide) is a biochemical,cross-linking agent reagent that can be used as a biological material, during the formation of polymers or organic compound for life science related research.
S6310 N-(2-Acetamido)-2-Iminodiacetic acid N-(2-Acetamido)-2-Iminodiacetic acid (ADA buffer) is a biological buffer component and can be used as a pharmaceutical intermediate.
S6187 N-(5-Aminopentyl)acetamide N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound.
S5390 N-(Hytroxymethy)micotinamide N-(Hydroxymethyl)nicotinamide (Nikomethamide, Bilamid, N-hydroxymethylnicotinamide) is an antimicrobial agent.
E2548 N-(p-Coumaroyl) Serotonin N-(p-Coumaroyl) Serotonin (p-coumaroylserotonin) is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties, can inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca2+ release from sarcoplasmic reticulum.
S2985 N-Acetyl-5-hydroxytryptamine

N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin), a precursor of melatonin, is a potent and selective agonist of TrkB receptor.
S3128 N-Acetyl-D-galactosamine

N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite.
S3371 N-Acetyl-D-mannosamine

N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction.
S3087 N-Acetyl-DL-methionine

N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
S3094 N-Acetyl-L-alanine

N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.
S3318 N-Acetyl-L-arginine dihydrate

N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate is an endogenous metabolite.
S3109 N-Acetyl-L-leucine

N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
S6205 N-Acetyl-L-methionine N-Acetyl-L-methionine (Ac-Met-OH) is an L-methionine derivative that is nutritionally and metabolically equivalent to L-methionine. It is a superior ROS scavenger.
S6362 N-Acetyl-L-phenylalanine N-Acetyl-L-phenylalanine is a hazardous amphipathic metabolite of phenylalanine.
S6316 N-Acetyl-L-tyrosine N-Acetyl-L-tyrosine is an acetylated form of the amino acid, L-Tyrosine. It is involved in catecholamine production.
S5804 N-Acetylcysteine amide N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
S6257 N-Acetylglucosamine N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases.
S6245 N-Acetylglutamic acid N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.
S3098 N-Acetylglycine

N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid), a minor constituent of numerous foods, is not genotoxic or acutely toxic.
S4792 N-Acetylneuraminic acid N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
S6116 N-Acetylornithine N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate. It is a minor component of deproteinized blood plasma of human blood.
S9395 N-Benzoyl-(2R,3S)-3-phenylisoserine N-Benzoyl-(2R,3S)-3-phenylisoserine, also known as taxol side chain, is important for strong antitumor activity of taxol.
S0651 N-Butanoyl-L-homoserine lactone N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
E0199 N-butyl-N-(4-hydroxybutyl) nitrosamine

N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that induces high-grade, invasive tumors in the urinary bladder.
S6493 n-Butylidenephthalide n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide), isolated from the chloroform extract of Angelica sinensis (AS-C), contributes to a range of biological activities, including diminution of angina, platelet aggregation, proliferation, non-specific spasmosis.,
E0477 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
S3542 N-desMethyl EnzalutaMide N-desMethyl EnzalutaMide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide, which is an oral androgen receptor inhibitor for treatment of castration-resistant prostate cancer.
E0786 N-Desmethyltamoxifen N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
E2368 N-Desmethyltamoxifen hydrochloride N-Desmethyltamoxifen hydrochloride (N-Desmethyl tamoxifen HCl), the primary metabolite of tamoxifen, is an estrogen response modifer and protein kinase C inhibitor with IC50 of 25 µM.
E2957 N-Dodecyl beta-D-maltoside N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a derivatives of pyrene (Py). It is alkyl maltopyranoside detergent, especially in transporters and respiratory complexes. N-Dodecyl-β-D-maltoside has also been employed in applications such as in the purification and stabilization of RNA polymerase and detection of protein-lipid interactions.
E2637 N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3-toluidine N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3-toluidine (TOOS) is a chromogenic agent used for catalase spectrophotometric determination.
S3328 N-Formyl-L-methionine

N-Formyl-L-methionine (For-Met-OH) is an endogenous metabolite.
E1313 N-Formyl-Met-Leu-Phe (fMLP) N-Formyl-Met-Leu-Phe (fMLP) is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) with Ki of 38 nM. It stimulates aggregation of leukocytes.
S3125 N-Formylglycine

N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite.
E0187 N-hydroxymethyl succinimide N-hydroxymethyl succinimide is used as pharmaceutical intermediate.
S6181 N-Isovaleroylglycine N-Isovaleroylglycine is an acyl glycine that is normally minor metabolites of fatty acids.
S6184 N-Methylhydantoin N-Methylhydantoin (1-Methylhydantoin, Dioxy-creatinine) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam.
S3321 N-Methylnicotinamide

N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.
S6056 N-Methylsarcosine N-Methylsarcosine (N,N-Dimethylglycine, (Dimethylamino)acetic acid) is a natural N-methylated glycine that is used in the development of glycine-based ionic liquids and emulsifiers.
E0158 N-Nitroso-N-methylurea

N-Nitroso-N-methylurea (NMU, MNU, NMH, 1-Methyl-1-nitrosourea, N-Methyl-Nnitrosourea, Methylnitrosourea) is a highly reliable carcinogen, mutagen, and teratogen.
E0136 N-Nitrosodiethylamine

N-Nitrosodiethylamine (N-Nitroso-diethylamine, NDEA, diethylnitrosamine, DEN) is DNA reactive after bioactivation and produces tumors in many animal species.
E4030 N-p-Tosyl-L-phenylalanine chloromethyl ketone N-p-Tosyl-L-phenylalanine chloromethyl ketone (Tosyl phenylalanyl chloromethyl ketone, TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis.
E0905 N-p-trans-Coumaroyltyramine

N-p-trans-Coumaroyltyramine is an alpha-glucosidase inhibitor.
E2201 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.
S0057 N-Succinimidyl-S-acetylthioacetate (SATA) N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent which introduces thiol-groups into protein molecules. N-Succinimidyl-S-acetylthioacetate (SATA) adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form.
S3949 N-Sulfo-glucosamine sodium salt N-Sulfo-glucosamine sodium salt (N-sulfoglucosamine sodium salt) is a member of the class of compounds known as hexoses that is soluble (in water) and an extremely strong acidic compound. It locates in the cytoplasm within the cells.
S6975 N-Vanillyldecanamide N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum, which can significantly reduce the radical length of Lactuca sativa seedling in a dose-dependent manner.
E4450 N6-Cyclopentyladenosine N6-Cyclopentyladenosine is an adenosine derivative and a potent adenosine receptor agonist with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.
S7589 N6022 N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.
E1812 N6F11 N6F11 is an inducer of ferroptosis. N6F11 is bound to the RING domain of the E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of glutathione peroxidase 4 (GPX4), resulting in proteasomal degradation.
E1068 Nab-Paclitaxel Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
S4051 Nabumetone Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
S0346 NAcM-OPT NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
S2518 NAD+ NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
S6349 NADH Disodium Salt Hydrate NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle.
S3105 Nadifloxacin Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.
S5023 Nadolol Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.
E4420 NADP sodium salt NADP sodium salt, a nicotinamide adenine dinucleotide, is a coenzyme that plays a vital role in various metabolic reactions within living cells. NADP sodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH).
E1689 NADPH tetrasodium salt NADPH tetrasodium salt is a ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It plays a crucial role as a cofactor in the biosynthesis of nucleotides, proteins, and fatty acids. It is essential for neutralizing elevated levels of reactive oxygen species (ROS) generated by increased metabolic activity.
S1386 Nafamostat mesilate (FUT-175) Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.
S4042 Nafcillin Sodium Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.
S5472 Nafronyl oxalate salt Nafronyl oxalate salt is the oxalate salt form of nafronyl, which is a selective antagonist of 5-HT2 receptors and a vasodilator used in the management of peripheral and cerebral vascular disorders.
S3156 Naftifine HCl Naftifine(AW 105-843) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis, probably involves selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.
S2126 Naftopidil Naftopidil (KT-611) is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.
S1387 Naftopidil DiHCl Naftopidil DiHCl (Flivas, KT-611, Avishot,BM-15275) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
S2328 Nalidixic acid Nalidixic acid (NSC-82174) is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
E1905 Nalidixic acid sodium salt Nalidixic acid sodium salt is an inhibitor of bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA supercoiling during replication, making it an effective quinolone antibiotic against both gram-positive and gram-negative bacteria.
E2868 Naloxegol Oxalate Naloxegol oxalate (NKTR-118 oxalate) is a μ-opioid-receptor antagonist with a Ki of 33.8 nM. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.
S0498 Namodenoson (CF-102) Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
S1450 Nanchangmycin Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.
S4992 Nanofin Nanofin (2,6-Dimethylpiperidine, Lupetidine, Naniopinum) is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.
S8667 Nanvuranlat (JPH203) Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
S7977 Napabucasin (BBI608) Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.
S2519 Naphazoline HCl Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
S8745 Naporafenib (LXH254) Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.
S5177 Naproxen Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.
S1626 Naproxen Sodium Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
S8412 Naquotinib(ASP8273) Naquotinib (ASP8273) is an orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.
S1488 Naratriptan HCl Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.
E1124 Narciclasine Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
E3214 Nardostachyos Rhizoma Extract Nardostachyos Rhizoma Extract is extracted from Nardostachyos Rhizoma, which is used in the treatment of cardiovascular disorders.
S2394 Naringenin Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
S9440 Naringenin chalcone Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.
S2329 Naringin Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
S2389 Naringin Dihydrochalcone Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.
S9242 Narirutin Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.
E0806 Narmafotinib Narmafotinib (AMP-945) is an inhibitor of focal adhesion kinase (FAK).
S6939 Nastorazepide Nastorazepide (Z-360), a cholecystokinin-2/gastrin receptor (CCK2/gastrin receptor) antagonist, combines with gemcitabine prolonged survival and reduces gemcitabine-induced vascular endothelial growth factor (VEGF) expression in a pancreatic carcinoma orthotopic xenograft mouse.
S1517 Natamycin Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference
S2489 Nateglinide Nateglinide (Starlix,A-4166,SDZ DJN 608) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.
E3568 Natural indigo Extract Natural Indigo Extract is extracted from Polygonum tinctorium, which suppress sodium dextran sulfate-induced colitis through interleukin-10-related pathway.
L7600 Natural Organic Compound Library A unique collection of 1252 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
L1410 Natural Phenol Compound Library A unique collection of 570 natural phenol compounds for high throughput screening (HTS) and high content screening (HCS).
L1400 Natural Product Library A unique collection of 3061 natural products for high throughput screening (HTS) and high content screening (HCS).
L1420 Natural Terpenoid Compound Library A unique collection of 356 natural terpenoid compounds for high throughput screening (HTS) and high content screening (HCS).
E1047 NAV-2729 NAV-2729, an inhibitor of Arf6 activation which directly binds to Arf6, also inhibits all Arf guanine nucleotide exchange factors (ArfGEFs) with a strongest effect against BRAG2 and Arf1 .
S8506 Navarixin (SCH-527123) Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
S1001 Navitoclax (ABT-263) Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
S8957 Navoximod Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.
S7824 Nazartinib (EGF816) Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.
S0338 NB 598 NB-598 is a potent, competitive squalene epoxidase (SE) inhibitor. NB-598 suppresses cholesterol biosynthesis.
E0943 NBD-556 NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
S0838 NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.
S9686 NBQX (FG9202) NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase, MAP4K7) with an IC50 value of 21 nM.
E0132 NCGC00244536

NCGC00244536 is a novel KDM4 Inhibitor with an IC50 of ∼10 nM.
S9677 NCGC00378430 NCGC00378430 is an inhibitor of the SIX1/EYA2 complex that significantly suppresses breast cancer-associated metastasis in vivo without significantly altering primary tumor growth.
S8619 NCT-503 NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with the IC50 value of 2.5 μM. It is inactive against a panel of other dehydrogenases and shows minimal cross-reactivity in a panel of 168 GPCRs.
S8377 ND646 ND-646 is an allosteric inhibitor of the ACC (Acetyl-coA carboxylase) enzymes that prevents ACC subunit dimerization to suppress fatty acid synthesis with IC50 of 3.5 nM and 4.1 nM for hACC1 and hACC2, respectively.
S8878 NDI-091143 NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an IC50 of 2.1 nM in the ADP-Glo assay.
S0844 NDMC101 NDMC101 inhibits osteoclastogenesis which also ameliorates paw swelling and inflammatory bone destruction, associating with the inhibition of such transcription factors as NF-κB and NFATc1 as well as multiple protein kinases, including p38, ERK, and JNK.
S6850 NE 52-QQ57 NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
S5739 Nebivolol Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S1549 Nebivolol hydrochloride (R-65824) Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.
A2048 Necitumumab (anti-EGFR) Necitumumab (anti-EGFR) is an epidermal growth factor receptor (EGFR) antagonist that can be used in combination with gemcitabine and cisplatin for the first-line treatment of patients with metastatic squamous non-small cell lung cancer.
S8641 Necrostatin 2 racemate (Nec-1s) Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
S8037 Necrostatin-1 Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.
E0301 Necrostatin-34 (Nec-34) Necrostatin-34 (Nec-34) is a small molecule inhibitor of RIPK1 kinase with an IC50 of 0.13 μM in L929 cells.
S8251 Necrosulfonamide Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).
S1826 Nedaplatin Nedaplatin(NSC 375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
S3400 NEDD8 inhibitor M22 NEDD8 inhibitor M22 (NAE-IN-M22) is a novel selective NEDD8 activating enzyme (NAE) inhibitor with GI50 of 5.5 μM in A549 cells.
S8586 Nedisertib (M3814) Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
S5398 Nefazodone hydrochloride Nefazodone hydrochloride (BMY-13754-1) is the hydrochloride salt form of nefazodone, which is an atypical antidepressant showing antagonistic activity on serotonin reuptake.
S5144 Neferine Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.
S1969 Nefiracetam Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.
S1458 Neflamapimod (VX-745) Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
S4180 Nefopam HCl Nefopam HCl(Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.
S1213 Nelarabine Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
S4282 Nelfinavir Mesylate Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.
E3258 Nelumbinis Folium Extract Nelumbinis Folium Extract is extracted from the leaves of Nelumbo nucifera and has good hypolipidemic, antioxidative, and anti-inflammatory bioactivities.
S3692 NEM (N-Ethylmaleimide) NEM (N-Ethylmaleimide) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.
S7937 Nemiralisib Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).
S8711 Nemtabrutinib (ARQ 531) Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.
S9648 NEO2734 NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.
S9286 Neobavaisoflavone Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
S9136 Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S9322 Neodiosmin Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.
S2332 Neohesperidin Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent.
S2331 Neohesperidin Dihydrochalcone (Nhdc) Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.
S3782 Neomangiferin Neomangiferin (Mangiferin 7-glucoside), a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action.
S2568 Neomycin sulfate Neomycin sulfate(Framycin sulfate) is an aminoglycoside antibiotic, used to treat bacteria infections.
S2654 Neoruscogenin Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).
S2490 Neostigmine Bromide Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.
S4442 Neotame Neotame is a low-caloric and high-intensity artificial sweetener that reduces the alpha-diversity and altered the beta-diversity of the gut microbiome.
E0760 Neotuberostemonine Neotuberostemonine (NTS), one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, has a significant effect on BLM-induced pulmonary fibrosis by inhibiting macrophage recruitment and M2 polarization protective effect.
S1255 Nepafenac Nepafenac (AHR 9434, AL 6515) is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.
S2695 Nepicastat (SYN-117) HCl Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
S6075 Nepsilon-Acetyl-L-lysine Nepsilon-Acetyl-L-lysine is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.
E0516 Nequinate Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections, also inhibits xanthine oxidoreductase (XOD) activity.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
S2150 Neratinib Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
S4970 Nerol Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis.
S5345 Nerolidol Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.
S6430 Nervonic acid Nervonic acid (cis-15-Tetracosenoic acid) is a long chain unsaturated fatty acid that is enriched in sphingomyelin and may enhance the brain functions and prevent demyelination.
S9373 Neryl acetate Neryl acetate (Nerol, Acetic acid neryl ester, cis-Geranyl), a chemical compound found in citrus oils, is a flavouring agent.
P1143 Nesiritide

Nesiritide (Brain Natriuretic Peptide-32 human; BNP-32) is an agonist of natriuretic peptide receptors (NPRs).
S6911 Nesolicaftor (PTI-428) Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.
E1425 Nesuparib Nesuparib (JPI-547, NOV140201) is a potential inhibitor of both PARP and tankyrases, with IC50 of 0.005 μM, 0.001 μM, 0.002 μM, and ND for TNKS1, TNKS2, PARP1, and PARP2, respectively. Nesuparib exhibits anti-tumor activity in BRCA-deficient xenograft models.
S8226 Netarsudil (AR-13324) 2HCl Netarsudil (AR-13324) is a ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
S5080 Neticonazole Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity.
S4878 Neticonazole Hydrochloride Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.
S4052 Netilmicin Sulfate Netilmicin Sulfate is a member of the aminoglycoside family of antibiotics.
S4654 Netupitant Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.
L4000 Neuronal Signaling Compound Library A unique collection of 1748 small molecule compounds with biological activity used for neurologic research and associated assays
P1122 Neuropeptide Y Neuropeptide Y (NPY), a 36 amino acid peptide widely distributed within central nervous system neurons, is a neuroprotective agent against β-amyloid neurotoxicity which influences the synthesis and the release of nerve growth factor (NGF) by cortical neurons.
E2700 Neutral Red Solution Neutral Red Solution, a nitrogenous pH-indicator, is an indicator for the internal acidification of thylakoids, which can stain lysosomes red.
S1742 Nevirapine (NSC 641530) Nevirapine (NSC 641530,NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
E1235 NF-56-EJ40 NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.
L5500 NF-κB Signaling Compound Library A unique collection of 494 small molecules used for NF-κB signaling pathway research which plays a key role in immunology/inflammation and cancer.
E0796 NF-κB-IN-1 NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor, which acts by directly inhibiting inhibitory κB kinase (IKK).
E1351 NF-κΒ activator 1 NF-κΒ activator 1(Compound 32) is a potent NF-κΒ activator, with an EC50 of 0.9 μM.
S6540 NG 52 NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively.
S8868 NG25 NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.
S8750 NGI-1 NGI-1 is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.
S8603 NGP 555 NGP 555 is a small-molecule modulator of γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.
S1246 NH2-PEG3-C2-NH-Boc NH2-PEG3-C2-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
E0807 NHWD-870 NHWD-870 inhibits CSF1 expression through suppressing BRD4 and its target HIF1α.
E0494 NI-42 NI-42 is a biased, potent inhibitor of the of the bromodomain and PHD finger-containing (BRPF) with IC50s of 7.9, 48, 260 nM for BRPF1/2/3.
S0183 NIBR189 NIBR189 is a potent antagonist of the Epstein-Barr virus-induced gene 2 (EBI2, GPR183) receptor with IC50 of 16 nM for binding and 11 nM for function, respectively.
S4265 Nicaraven Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.
S4866 Nicarbazin Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug.
S5255 Nicardipine Nicardipine is a potent calcium channel blockader with marked vasodilator action.
S4181 Nicardipine HCl Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.
S4797 Nicergoline Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions.
S3030 Niclosamide Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
S1971 Nicorandil Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).
S3267 Nicotiflorin (Kaempferol-3-O-rutinoside) Nicotiflorin (Kaempferol-3-O-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
S1899 Nicotinamide Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
S4785 Nicotinamide N-oxide Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the CXCR2 receptor.
S2935 Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
S1744 Nicotinic Acid Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family.
S4995 Nicotinic acid N-oxide Nicotinic acid N-oxide (Oxiniacic acid, Nicotinic acid 1-oxide) is nicotinic acid derivative that acts as a ligand and forms lead-carboxylate complexes having phosphorescent properties.
S3322 Nicotinuric acid

Nicotinuric acid (NUA) is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid.
E0068 NiCur NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
S0037 Nidufexor (LMB-763) Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR).
E3800 Nidus Collocaliae Extract Nidus Collocaliae Extract is drawed from Nidus Collocaliae, which has anti-H5N1 virus effect probably through resisting hemagglutinin.
S1808 Nifedipine Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.
S3018 Niflumic acid Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
S3966 Nifuratel Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action.
S4182 Nifuroxazide Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
S6459 Nifurtimox Nifurtimox (BAY-2502) is an antiprotozoal agent.
E3274 Nigella Sativa Extract (Herb) Nigella Sativa Extract (Herb) which is extrcated from Nigella Sativa, which has been widely used as an antihypertensive, liver tonic, diuretic, digestive, anti-diarrheal, appetite stimulant, analgesic, anti-bacterial, and for skin disorders.
E3275 Nigella Sativa Extract (Seed) Nigella Sativa Extract (Seed) is extrcated from the seeds of Nigella Sativa and may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, and antioxidant properties.
S6653 Nigericin sodium salt Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
S6529 NIH-12848 NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM.
S8941 NIK SMI1 NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.
S6818 Nile Red Nile Red (Nile Blue A oxazone, Phenoxazone 9) is an excellent vital fluorescent stain for the detection of intracellular lipid droplets in the presence of a hydrophobic environment. Nile Red is applied for staining intracellular lipids, hydrophobic domains of proteins and lysosomal phospholipid inclusions.
S1033 Nilotinib Nilotinib is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
S5205 Nilotinib hydrochloride Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
S4895 Nilotinib hydrochloride monohydrate Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
S4836 Nilutamide Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.
S2721 Nilvadipine Nilvadipine (ARC029, FR34235,FK235) is a potent calcium channel blocker with an IC50 of 0.03 nM.
S2040 Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
S1747 Nimodipine Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
S6411 Nimorazole Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity.
S5293 Nimustine Hydrochloride Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
S6870 Ningetinib Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.
S1010 Nintedanib Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.
S5234 Nintedanib Ethanesulfonate Salt Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.
A2948 Nipocalimab (Anti-FcRn) (FCGRT & B2M) Nipocalimab (anti-FcRn) (FCGRT & B2M) is a fully human monoclonal antibody that targets the neonatal crystallizable fragment receptor (FcRn) with potential immunomodulating activity. MW: 142.12 KD.
S2741 Niraparib (MK-4827) Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.
S7625 Niraparib tosylate Niraparib tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.
S9866 Nirmatrelvir (PF-07321332)

Nirmatrelvir (PF-07321332) is an reversible covalent inhibitor of SARS-CoV-2 main protease (Mpro, also referred to as 3CL protease) with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.
S8018 Nirogacestat (PF-03084014) Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.
S1748 Nisoldipine Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
S1627 Nitazoxanide Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.
S4422 Nitenpyram Nitenpyram(Bestguard,Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.
S4232 Nithiamide Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.
E3417 Nitidum Extract Nitidum Extract is extracted from Zanthoxylum Nitidum, which is well known for its anti-inflammatory and analgesic effects.
S5325 Nitisinone (NTBC) Nitisinone (NTBC) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.
S2491 Nitrendipine Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.
E0829 Nitrocaramiphen hydrochloride Nitrocaramiphen hydrochloride is an antagonist of muscarinic acetylcholine receptor M1 (mAChR M1), which can completely remove the hyperpolarizing effect of muscarine.
S1644 Nitrofural Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)
S4536 Nitrofurantoin Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
E4025 Nitrotetrazolium Blue chloride Nitrotetrazolium Blue chloride (Nitro blue tetrazolium chloride, NBT) is a chromogenic substrate used for detecting oxygen metabolites in cells, staining histological tissue sections, and labeling probe-target interactions. Nitrotetrazolium blue chloride is paired with 5-bromo-4-chloro-3-inolyl phosphate (PCIB) to detect alkaline phosphatase activity.
S4591 Nitroxoline Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.
A2002 Nivolumab (anti-PD-1) Nivolumab (anti-PD-1) is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD.
S1890 Nizatidine Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
E0441 NK-252 NK-252 is an activator of Nrf2 and interacts with the Nrf2-binding site of Keap1.
S6548 NKL 22 NKL 22 is a selective inhibitor of HDAC with IC50 of 78 µM.
S0767 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
S3510 NLX-101 NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors.
S0352 NLX-204 NLX-204 is a potent, selective agonist of ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor with pKi of 10.19.
S7072 NMDA (N-Methyl-D-aspartic acid) NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
S0509 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.
S7282 NMS-E973 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
S8363 NMS-P118 NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).
E0133 NNMTi

NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM.
S2333 Nobiletin Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.
S2775 Nocodazole Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.
S0004 NOD-IN-1 NOD-IN-1 (MDK19922, Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2 with IC50 of 5.74 μM and 6.45 μM, respectively.
S3245 Nodakenetin Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S9260 Nodakenin Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.
S2863 Nodinitib-1 (ML130) Nodinitib-1(ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.
E0707 Nomegestrol Acetate Nomegestrol Acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
S5045 Nomilin Nomilin is a triterpenoid present in common edible citrus fruits with putative anticancer properties.
S6332 Nonadecanoic acid Nonadecanoic acid (Nonadecylic acid, Nonadecanoate) is a long saturated fatty acid found in ox fats and vegetable oils, and in Staphylococcus. It can be used as a phermone by certain insects.
E4471 Nonaethylene glycol Monododecyl ether Nonaethylene glycol monododecyl ether is a non-ionic surfactant. It has been used to assess a procedure for analyzing total lipid and triacylglycerol using bovine liver tissue.
S4949 Nonanoic acid Nonanoic acid (Pelargonic acid, Nonoic acid) is a naturally occurring fatty acid found in both vegetable and animal fats.
S9071 Nootkatone Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.
S9737 Nor-NOHA acetate Nor-NOHA acetate (Nω-Hydroxy-nor-L-Arginine acetate, N-OMega-hydroxy-L-norarginine acetate, N-Hydroxy-nor-L-arginine acetate) is a reversible, competitive inhibitor of arginase. Nor-NOHA inhibits arginase activity in aorta with an IC50 of less than 1 μM, that is, similar to its effects on liver arginase (IC50 = 0.5 μM).
S2615 Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
S3759 Norcantharidin Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
S3984 Nordihydroguaiaretic acid (NDGA) Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.
E2944 Norepinephrine hydrochloride Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.
E2964 Norepinephrine tartrate Norepinephrine tartrate is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.
S4040 Norethindrone Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.
S5785 Norethindrone acetate Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.
S6589 Norethisterone Enanthate Norethisterone Enanthate (Norethindrone Enanthate) is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women.
S1509 Norfloxacin Norfloxacin (MK-0366) is a broad-spectrum antibiotic. Norfloxacin (MK-0366) targets bacterial gyrase and topoisomerase IV enzymes.
E0527 Norgestimate Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity.
S5709 Norgestrel Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.
E2632 Norharmane Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.
S9092 Norisoboldine Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells.
S3698 Nortriptyline hydrochloride Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
S4897 Nortropine Hydrochloride Nortropine Hydrochloride (Nortropeno) is a secondary metabolite of tropine derivative drugs, such as atropine and benztropine.
S6923 NOTA NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid is a bifunctional chelating agent which acts as the framework to construct PET imaging tools. It is also used for probe design and signal amplification via the multivalent effect and also has potential applications as diagnostic gallium radiopharmaceuticals.
S3785 Notoginsenoside R1 Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.
S5475 Novaluron Novaluron (Rimon) belongs to the class of insecticides called insect growth regulators with pesticide properties.
S2492 Novobiocin Sodium (NSC 2382) Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
S2962 NP-G2-044 NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.
S0452 NP118809 NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.
S4453 NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
S7669 NPS-1034 NPS-1034 is a dual Met (c-Met)/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
S2633 NPS-2143 NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.
E1208 NPX800 NPX800 is a potent heat shock factor 1 (HSF1) inhibitor, which has the potential for cancer research.
S0141 NQ301 NQ301 (Compound 211), an antiplatelet and antithrombotic agent, is a selective CD45 inhibitor with IC50 of 200 nM. NQ301 inhibits thromboxane A2 receptor (TXA2) and synthase activity in rabbit platelets.
S9903 NRD167

NRD167 is a potent and selective SIRT5 inhibitor.
S6755 NS 11394 NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes.
S0518 NS 1738 NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), with respect to positive modulation of Xenopus laevis oocyte α7 nAChR with EC50 of 3.4 μM, as well as a comparable efficacy at the rat α7 nAChR with EC50 of 3.9 μM.
S0462 NS-1619 NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.
S8433 NS-398 (NS398) NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.
S5773 NS1643 NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents.
S2955 NS1652 NS1652 is a reversible chloride channel blocker, potently inhibits the chloride conductance (IC50 = 1.6 μM) in human and mouse red blood cells, but only weakly volume activated anion conductance (VRAC) (IC50 = 125 μM) in HEK293 cells.
E0030 NS309

NS309 is a potent and selective activator of human Ca2+ -activated K+ channels of SK and IK types with an EC50 of 150  nM for hSK3 channel, and displays no activity at BK channels.
E0325 NS3623 NS3623 is an activator of human ether-a-go-go-related gene hERG1/KV11.1 potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels.
S0090 NS6180 NS-6180 is a highly selective inhibitor of KCa3.1 ion channel with IC50 value of 9 nM, which inhibits T cell activation and inflammation.
S6174 NS8593 Hydrochloride NS8593 is a potent negative gating inhibitor of small conductance Ca2+ -activated K+ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM.
S3385 NSAH NSAH (HNASH) is a reversible and competitive nonnucleoside ribonucleotide reductase (RNR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
S6716 NSC 185058 NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways.
S2678 NSC 207895 NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
S7149 NSC 319726 (ZMC1) NSC 319726 (ZMC1) is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
S6524 NSC 42834 NSC42834 (JAK2 Inhibitor V, Z3) is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.
S4922 NSC 632839 NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.
E1520 NSC 663284 NSC 663284(DA-3003-10) is a potent, cell-permeable, and irreversible dual specificity phosphatase inhibitor of Cdc25, and exhibits an IC50 of 0.21 μM for Cdc25B2 and is 20 and 450-fold highly selective against Cdc25B2. NSC 663284 also inhibits NSD2 with an IC50 of 170 nM via a direct interaction with the catalytic SET domain.
S1155 NSC 74859 (S3I-201) NSC 74859 (S3I-201) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.
S7940 NSC12 NSC12 (NSC 172285) is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity.
S0231 NSC15364 NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization, concomitant with an inhibition of apoptosis.
E1723 NSC16168 NSC16168 is a specific inhibitor of ERCC1-XPF, and exhibits an IC50 value of 0.42 μM in a high throughput screen (HTS) assay, respectively. NSC16168 inhibits DNA repair and potentiates cisplatin efficacy in cancer.
S6566 NSC23005 Sodium NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM).
E0351 NSC232003 NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor that binds to the 5mC binding pocket of the SRA domain of UHRF1. NSC232003 modulates DNA methylation in a cellular context.
S8149 NSC348884 NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
S4451 NSC45586 NSC45586 is an inhibitor of PHLPP (Pleckstrin homology domain and leucine-rich repeat protein phosphatase), which is selective for PHLPP1 and PHLPP2.
S9869 NSC622608 NSC622608 is a first small-molecule ligand for V-domain Ig Suppressor of T-cell Activation (VISTA) with an IC50 of 4.8 μM in TR-FRET assay.
S8182 NSC87877 NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
S6777 NSC95397 NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
S5620 NSI-189 NSI-189, a small molecule with enhanced neurogenic activity, is a potential antidepressant for the treatment of major depressive disorder (MDD), cognitive impairment and neurodegeneration.
S8228 NT157 NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
S7730 NU1025 NU1025 (NSC 696807) is a potent PARP inhibitor with IC50 of 400 nM.
S5316 NU2058 NU2058 (O(6)-Cyclohexylmethylguanine) is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.
S7114 NU6027 NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
S2893 NU7026 NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.
S2638 NU7441 (KU-57788) NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
S3821 Nuciferine Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
L7200 Nucleoside Analogue Library A unique collection of 229 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
S0433 Nucleozin Nucleozin is an antivirus agent that targets influenza A nucleoprotein (NP). Nucleozin triggers the aggregation of NP and inhibits its nuclear accumulation.
S3313 Nudifloric Acid

Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid), isolated from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities.
S1061 Nutlin-3 Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.
S8059 Nutlin-3a Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.
S8065 Nutlin-3b Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
S9473 Nuzhenide Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity.
S6501 NVP 231 NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage.
S8981 NVP-2 NVP-2, a potent, selective, non-neurotoxic and ATP-competitive cyclin dependent kinase 9 (CDK9) inhibitor with IC50 of 0.514 nM for CDK9/CycT activity and induces cell apoptosis.
S1088 NVP-ADW742 NVP-ADW742 (GSK 552602A) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
S1034 NVP-AEW541 NVP-AEW541 is a potent inhibitor of IGF-1R/InsR with IC50 of 150 nM/140 nM in cell-free assays, greater potency and selectivity for IGF-1R in a cell-based assay.
S1498 NVP-BEP800 NVP-BEP800 (VER82576) is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits>70-fold selectivity against Hsp90 family members Grp94 and Trap-1.
E2835 NVP-BHG712 isomer NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EphA2 and EphB4.
S2686 NVP-BSK805 2HCl NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.
S2761 NVP-BVU972 NVP-BVU972 is a selective and potent Met (c-Met) inhibitor with IC50 of 14 nM.
S7875 NVP-CGM097 NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.
E1204 NVP-DKY709 NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.
E2404 NVP-LCQ195 NVP-LCQ195 (AT9311, LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
S0230 NVP-VID-400 NVP-VID-400 (SDZ285428) is an inhibitor of CYP51. NVP-VID-400 (SDZ285428) inhibits T. cruzi and T. brucei with I/E2a(5 min) of both <1 and I/E2(60 min) of 9 and 35, respectively.
S6757 NVR 3-778 NVR 3-778, belonging to the SBA (sulfamoylbenzamide) class, is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator). NVR 3-778 exhibits anti-HBV activity.
S8264 NVS-PAK1-1 NVS-PAK1-1 is a potent and selective allosteric p21-activated kinase 1 (PAK1) inhibitor with an IC50 of 5 nM.
S6668 NVS-ZP7-4 NVS-ZP7-4,a Zinc transporter SLC39A7 (ZIP7) inhibitor,is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
E1381 NX-2127 NX-2127 is a unique, potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells.
S5267 Nylidrin Hydrochloride Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S1934 Nystatin Nystatin(Fungicidin), which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
S9060 Nystose Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum.
S2989 Nα-Acetyl-L-asparagine

Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) is an endogenous metabolite that exists in human brain.
S3345 Nα-Acetyl-L-lysine

Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) is an active endogenous metabolite.
S5259 β-Nicotinamide Mononucleotide Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.