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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Apoptosis related

Natural Guanine Derivatives Exert PARP-Inhibitory and Cytoprotective Effects in a Model of Cardiomyocyte Damage under Oxidative Stress

44 views | Feb 13 2024

The compelling findings reveal the potential of guanine derivatives, particularly 7-methylguanine and 8-hydroxy-7-methylguanine, as potent inhibitors of PARP activation, offering promising avenues for therapeutic development in conditions associated with oxidative stress and inflammation. [Read the Full Post]

Reduced Zn2+ promotes retinal ganglion cells survival and optic nerve regeneration after injury through inhibiting autophagy mediated by ROS/Nrf2

74 views | Feb 13 2024

Reduced mobile zinc (Zn2+) promotes retinal ganglion cell (RGC) survival and axonal regeneration post-optic nerve crush (ONC) injury by decreasing reactive oxygen species (ROS), activating Nrf2, and inhibiting autophagy, highlighting a potential therapeutic strategy via Zn2+ reduction using TPEN or conditional knockout of ZnT-3 in amacrine cells (ACs) for treating optic nerve damage. [Read the Full Post]

Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency

59 views | Feb 13 2024

The synergistic combination of Taxol and reversine has revolutionized chromosomal transfer protocols, significantly enhancing efficiency across various cell lines and paving the way for accelerated advancements in genetic and regenerative medical research. [Read the Full Post]

Enhancing or Quenching of a Mitochondria-Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+, and Stimulated Response of GSH

134 views | Feb 03 2024

The versatile TPE-FdU fluorescent probe, exhibiting pH-responsive behavior, selective Hg2+ ion detection, and intracellular mitochondrial visualization, represents a promising advancement with diverse applications in cell imaging, environmental monitoring, and biomedical research. [Read the Full Post]

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

39 views | Jan 30 2024

The study underscores the pivotal role of IGF2BP2 in acute myeloid leukemia, revealing its association with unfavorable prognosis, promotion of leukemia cell development through m6A-dependent regulation of key metabolic targets, and the promising therapeutic potential of the identified small-molecule compound (CWI1-2) in targeting IGF2BP2 for AML treatment. [Read the Full Post]

Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201

190 views | Jan 22 2024

Targeting the SUV39H1-H3K9me3 pathway in DIPG cells with chaetocin, and combining it with a DRD2 antagonist like ONC201, presents a promising strategy for effective treatment by exploiting vulnerabilities and overcoming resistance mechanisms. [Read the Full Post]

Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer

66 views | Jan 21 2024

The synthesized compounds, particularly 35a, 39a, and 47, exhibit potent nanomolar/sub-nanomolar cytotoxicity against a range of cancer cell lines, showcasing promising anti-cancer potential via NAMPT inhibition and subsequent disruption of the NAD+ pathway, leading to cell death. [Read the Full Post]

Gastrodin overcomes chemoresistance via inhibiting Skp2-mediated glycolysis

78 views | Jan 18 2024

The study highlights the potential of targeting the Skp2-Akt axis and utilizing gastrodin, inhibiting HK2-mediated glucose metabolism and promoting apoptosis, as a promising combined therapeutic approach for overcoming cisplatin resistance in oral squamous cell carcinoma (OSCC). [Read the Full Post]

Lactate Dehydrogenase Gene Family in Spirometra mansoni (Cestoda: Diphyllobothriidea)-Phylogenetic Patterns and Molecular Characteristics

97 views | Jan 16 2024

This study on Spirometra mansoni identified 19 novel LDH members, delineated their expression patterns across developmental stages, characterized their structural features, enzymatic properties, and inhibition, providing fundamental insights into the diverse roles of LDHs in this parasite and related taxa. [Read the Full Post]

Identification of upregulated genes in glioblastoma and glioblastoma cancer stem cells using bioinformatics analysis

169 views | Dec 29 2023

This comprehensive study uncovered potential therapeutic targets for glioblastoma by identifying highly coexpressed genes in cancer stem cells, highlighting DUSP6 and SOX2 as prognostically relevant hub genes and proposing (E/Z)-BCI and BCI compounds as promising anti-cancer agents via strong binding interactions with DUSP6's ERK2 binding domain. [Read the Full Post]