Choose Your Country or Region

Category

PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- ATM/ATR
- PDK
- AMPK
- DNA-PK
- PTEN
- MELK
- PP2A
- PIKfyve
- PI4K
- PDPK1
Epigenetics
- HDAC
- AMPK
- PARP
- JAK
- Pim
- HIF
- PKC
- Aurora Kinase
- Sirtuin
- DNA Methyltransferase
- Histone Acetyltransferase
- Epigenetic Reader Domain
- Histone Methyltransferase
- Histone Demethylase
- SETD
- NSD
- G9a/GLP
- FTO
- MLL
- MicroRNA
- JMJD
- PRMT
- EZH1/2
- PAD
- LSD1
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
Methylation
- DNA Methyltransferase
- NNMT
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- MLL
- JMJD
- PRMT
- EZH1/2
- NSD
- FTO
- LSD1
- MAT2A
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- TNF-alpha
- COX
- CCR
- Histamine Receptor
- IL Receptor
- Nrf2
- ROS
- NADPH-oxidase
- Anti-infection
- AhR
- IDO/TDO
- gp120/CD4
- NOD
- CXCR
- MALT
- LTR
- TLR
- NOS
- Immunology & Inflammation related
- Pyroptosis
- NLRP3
- Neuraminidase
- cGAS
- PGDS
- SIK
- TRIF
- FKBP
- PKR
- AKR1C
- Parasite
- TpoR
- MmpL3
- Heme Oxygenase
- Antioxidant
- MyD88
- eIF
- MIF
- STING
- Nur77
- Galectin
- Complement System
- Prostaglandin Receptor
- SPHK
- Glutathione
- PGES
- β-lactamase
- IFN
- TBK1
- FLAP
- IRAK
- Arginase
- Interleukins
Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- Ephrin receptor
- CSF-1R
- ACK
- Trk receptor
- BTK
- DYRK
- RON
- Fer kinase
- ETK/BMX
- Mertk
- Axl
- Tyro3
- Pyk2
- ROS1
- DDR
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- STAT
- Bcl-2
- Caspase
- p53
- TNF-alpha
- MDM2/MDMX
- Survivin
- Ras
- c-RET
- IAP
- RIP kinase
- PERK
- ASK
- Ferroptosis
- Myc
- PFKFB
- cytohesin
- FKBP
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- Bcl-6
- Thymidylate Synthase
- Pyroptosis
- DAPK
- Nur77
- PKD
Autophagy
- CXCR
- Nrf2
- LRRK2
- Autophagy
- OGA
- Beclin
- LC3
- cGAS
- ULK
- FKBP
- Mitophagy
- Heme Oxygenase
ER stress & UPR
- JNK
- HSP (HSP90)
- ROS
- PERK
- ASK
- eIF
- PKR
- Antioxidant
- ATF-6
- PDI
- IRE1
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- TOPK
- ASK
- Mixed Lineage Kinase
- MNK
- KLF
- TAK1
- ERK
- MAP4K
- MAPKAPK2
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- MPS1
- Dynamin
- PAK
- Integrin
- Gap-Junction
- MLCK
- Actin
- Cardiac Myosin
- PORCN
- TACC3
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- TOPK
- Myc
- Serine/threonin kinase
- PAK
- Rho
- MPS1
- DYRK
- Casein Kinase
- PERK
- Mad2
- Haspin Kinase
- Choline kinase
- AP-1
- BMI-1
- DOCK
- p21
- FOXM1
- eIF
- Nur77
- TACC3
- PP2A
- RUNX
- PFKFB
- LIM kinase
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- MDM2/MDMX
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- G-quadruplex
- RNR
- NUDIX
- eIF
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- BMI-1
- Pax
- FENs
- OGG1
- Thymidylate Synthase
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- Stemness kinase
- KLF
- OCT
- Casein Kinase
- ERK
- SFRP
- Fascin
- PORCN
- Notch
- Secretase
Hippo
- LATS
- TEAD
- MAP4K
- MST
- YAP
Ubiquitin
- Proteasome
- DUB
- p97
- E1 Activating
- SUMO
- E2 conjugating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- BACE
- Trk receptor
- GlyT
- NMDAR
- CaMK
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- Serotonin Transporter
- CCK receptor
- Neurotensin Receptor
- COMT
- Melanocortin Receptor
- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
- BChE
- EAAT
- Neurokinin Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- MALT
- Nrf2
- ROS
- NOD
- Antioxidant
- AP-1
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- TAAR
- CaSR
- Glucagon Receptor
- LTR
- Parathyroid Hormone Receptor
- NPY receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- FPR
- GRK
- Leukotriene
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- CRFR
- PKG
- Bradykinin Receptor
- Angiotensin Receptor
- Bombesin Receptor
- Imidazoline Receptor
- Neurotensin Receptor
- RGS
- Melanocortin Receptor
- Sigma Receptor
- Taste Receptor
- PAR
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
- CCK receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- MCT
- Amino acid transporter
- OAT
- Mechanosensitive Channel
- BCRP
- NKCC
- NCX
- TRP Channel
- OATP
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Decarboxylase
- Casein Kinase
- Thioredoxin
- Retinoid Receptor
- Transferase
- FXR
- Neprilysin
- PP2A
- FTO
- RUNX
- SREBP
- AdipoR
- PAD
- CPT
- SCD
- CAR
- AP-1
- LDH
- Carbohydrate Metabolism
- γGCS
- SSTR
- PAI-1
- FTase
- SOD
- ATP-citrate lyase
- FAO
- SGK
- GOT
- 3-MST
- GTPCH
- glucocerebrosidase
- FABP
- Serine hydrolase
- Epoxide Hydrolase
- ACSS2
- ROR
- Catalase
- THR
- PDHK
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PGC-1α
- PARG
- Xanthine Oxidase
- Mannosidase
- Leukotriene
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Acetyl-CoA carboxylase
- Adenosine Kinase
- OXPHOS
- Glutathione
- PCSK9
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PGDS
- Mitochondrial pyruvate carrier
- PREP
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- PAD
- PCSK9
- Secretase
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- Fungal
- CMV
- Neuraminidase
- Parasite
- Antiviral
- Thioredoxin Reductase
- Bacterial
- β-lactamase
- Antibiotics
- 3C-Like Protease
- Enterovirus
- COVID-19
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
- HBV
- HIV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

Archives

Popular Post

ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

FOXM1

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer

203 views | Sep 27 2023

RNF112 suppresses gastric cancer progression by directly ubiquitinating FOXM1, making the RNF112/FOXM1 axis a potential prognostic biomarker and therapeutic target in gastric cancer. [Read the Full Post]

FOXM1 augments sorafenib resistance and promotes progression of hepatocellular carcinoma by epigenetically activating KIF23 expression

53 views | Sep 19 2023

The study revealed that upregulation of FOXM1 in hepatocellular carcinoma (HCC) cells contributes to sorafenib resistance and HCC progression by increasing the expression of KIF23, and targeting FOXM1 could be an effective treatment strategy for HCC. [Read the Full Post]