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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Wnt/beta-catenin

Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study

105 views | Jan 21 2024

The study utilizing Mendelian randomization suggests a causal link between longer leukocyte telomere length and a reduced risk of systemic sclerosis, implicating the influence of specific genetic variants in TERC and TERT genes. [Read the Full Post]

Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo

72 views | Jan 04 2024

"IWP-4 treatment of mesenchymal stem cells from human umbilical cord tissue enhances cardiac differentiation, leading to improved myocardial regeneration and functional recovery in a myocardial infarction rat model." [Read the Full Post]

CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis

101 views | Dec 30 2023

The study's findings suggest that CCT251545 in combination with chemotherapy demonstrates a potent synergistic effect by enhancing drug uptake through Rac1-dependent macropinocytosis and elevating NAD levels, providing a promising avenue for managing multidrug-resistant cancers. [Read the Full Post]

Retinoic acid delays murine palatal shelf elevation by inhibiting Wnt5a-mediated noncanonical Wnt signaling and downstream Cdc-42/F-actin remodeling in mesenchymal cells

111 views | Dec 10 2023

This study elucidates the mechanism by which retinoic acid disrupts palate development, causing cleft palate in mice, revealing the crucial role of Wnt5a-mediated noncanonical Wnt signaling downstream of Rho GTPase Cdc42 in regulating cytoskeletal remodeling and cell migration during the process. [Read the Full Post]

The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes

74 views | Nov 10 2023

A series of copper(I) complexes combining non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine ligands demonstrated potent anti-breast cancer stem cell activity, reducing cell viability and increasing intracellular reactive oxygen species (ROS) levels, potentially opening new avenues for breast cancer treatment. [Read the Full Post]

Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway

96 views | Oct 31 2023

This study demonstrates that IGFBP3 regulates the mineralization microenvironment during tooth development through its modulation of the DKK1-Wnt/beta-catenin axis, highlighting its potential importance in tooth regeneration and dental care. [Read the Full Post]

A novel denoising method for low-dose CT images based on transformer and CNN

112 views | Oct 28 2023

The paper proposes a novel LDCT image denoising method based on a transformer combined with a convolutional neural network (CNN), which effectively removes noise and improves image quality, outperforming state-of-the-art models in evaluation metrics such as PSNR, SSIM, and RMSE. [Read the Full Post]

Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice

187 views | Oct 27 2023

The study identified TNIK as a key kinase involved in procollagen I trafficking and demonstrated its potential as a therapeutic target for hepatic fibrosis. [Read the Full Post]

YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis

117 views | Oct 26 2023

This study provides evidence that the interaction between Yes-associated protein 1 (YAP) and β-catenin synergistically promotes H. pylori-induced gastric carcinogenesis and identifies shared downstream genes, CDX2, LGR5, and RUVBL1, potentially contributing to the pathogenesis of H. pylori-associated gastric cancer. [Read the Full Post]

Double crosslinked biomimetic composite hydrogels containing topographical cues and WAY-316606 induce neural tissue regeneration and functional recovery after spinal cord injury

90 views | Oct 21 2023

The study presents a multifunctional biomaterial system composed of acellularized spinal cord matrix, gelatin-acrylated-β-cyclodextrin-polyethene glycol diacrylate hydrogel, and aligned polycaprolactone microfibers, loaded with WAY-316606, which effectively promotes neural tissue regeneration and significantly improves motor function in rats with spinal cord injury. [Read the Full Post]