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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Retinoid Receptor

Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion

44 views | Feb 03 2024

Reduced retinoic acid signaling, induced by inhibitors or ethanol exposure, disrupts early neuroectodermal network regulation, increasing neural precursor proliferation and expanding the neural plate, thereby leading to the induction of neural tube defects during embryogenesis. [Read the Full Post]

Prognosis and personalized medicine prediction by integrated whole exome and transcriptome sequencing of hepatocellular carcinoma

47 views | Jan 08 2024

The comprehensive analysis of hepatocellular carcinoma mutations, particularly highlighting TP53 and LRP1B, suggests a tailored prognostic risk model for TP53 wild-type patients and identifies potential therapeutic implications, such as AM580, opening avenues for personalized treatment approaches. [Read the Full Post]

Novel pharmacotherapy targeting the positive symptoms of schizophrenia

36 views | Nov 02 2023

This manuscript provides an updated overview of novel pharmacotherapy targeting positive symptoms in schizophrenia, highlighting promising compounds and alternative biological systems for future research. [Read the Full Post]

CNKSR2, a downstream mediator of retinoic acid signaling, modulates the Ras/Raf/MEK pathway to regulate patterning and invagination of the chick forebrain roof plate

77 views | Mar 02 2023

The study found that CNKSR2, a novel mediator of retinoic acid (RA) signaling, plays a crucial role in the morphogenesis of the avian forebrain by modulating the Ras/Raf/MEK signaling, leading to proper invagination, cell proliferation, and patterning of the roof plate for the formation of the cerebral hemispheres. [Read the Full Post]

13-cis-retinoic acid (NSC 122758) in the treatment of children with metastatic neuroblastoma unresponsive to conventional chemotherapy: report from the Childrens Cancer Study Group

137 views | Mar 02 2023

The study conducted by the Children's Cancer Study Group on 13-cis-retinoic acid in children with advanced neuroblastoma showed no significant activity and the drug was not effective in treating the condition. [Read the Full Post]