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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Hydroxylase

The role of serotonin inhibition within the treatment of carcinoid syndrome

45 views | Nov 04 2023

Carcinoid syndrome, characterized by symptoms such as diarrhea, flushing, and abdominal pain, is primarily managed through the use of somatostatin analogues, surgical resection for potential cure, and other therapies such as loco-regional interventional radiological procedures, peptide receptor radionuclide therapy, and targeted medications. [Read the Full Post]

Gram-Scale Preparation of Cannflavin A from Hemp ( Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase

57 views | Nov 01 2023

Cannflavin A (CFA), a compound derived from Cannabis sativa, has been shown to effectively inhibit kynurenine-3-monooxygenase (KMO), an enzyme in the neurotoxic kynurenine pathway (KP), indicating its potential as a therapeutic agent for neuroinflammatory and neurodegenerative disorders related to KP metabolites. [Read the Full Post]

Dimethyloxalylglycine Attenuates Steroid-Associated Endothelial Progenitor Cell Impairment and Osteonecrosis of the Femoral Head by Regulating the HIF-1α Signaling Pathway

104 views | Jun 11 2023

Targeting hypoxia-inducible factor-1α (HIF-1α) in endothelial progenitor cells (EPCs) may offer a novel therapeutic approach for the treatment of steroid-associated osteonecrosis of the femoral head (SONFH) by alleviating glucocorticoid-induced endothelial impairment, promoting angiogenesis and osteogenesis, and enhancing the homing of EPCs to the injured endothelium. [Read the Full Post]

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

0 views | Oct 22 2022

Daniel J Lustberg et al. established a simple method for repeated assessment of stress-induced repetitive behaviors in mice. [Read the Full Post]

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

51 views | Oct 22 2022

Daniel J Lustberg et al. established a simple method for repeated assessment of stress-induced repetitive behaviors in mice. [Read the Full Post]

Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice

140 views | Mar 10 2022

Leticia Gil de Biedma-Elduayen et al. demonstrated that the modulation of the kynurenine pathway was an effective strategy for the treatment of ethanol dependence in both sexes. [Read the Full Post]

Treatment With Nepicastat Decreases Contextual Traumatic Memories Persistence in Post-traumatic Stress Disorder

202 views | Nov 28 2021

Raquel Martinho wt al. found that the increase in Npas4 and Bdnf mRNA expression in the hippocampus might be important to develop a weaker traumatic contextual memory after nepicastat treatment. [Read the Full Post]

Addiction and the kynurenine pathway: A new dancing couple?

314 views | Mar 23 2021

Nuria Morales-Puerto et al. discussed ethanol, nicotine, cannabis, amphetamines, cocaine and opioids and new prospects in the drug research field were proposed [Read the Full Post]

Lack of zinc finger protein 521 upregulates dopamine β-hydroxylase expression in the mouse brain, leading to abnormal behavior

323 views | Dec 10 2020

Nobutaka Ohkubo et al. suggested that the lack of ZFP521 upregulated the expression of DBH, which led to a decrease in the DA level and an increase in the NA level in the brain, resulting in abnormal behaviors. [Read the Full Post]

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

819 views | Mar 04 2020

De La Garza R 2nd et al. indicated that nepicastat is safe when co-administered with cocaine and may suppress its positive subjective effects, and may be viable as a pharmacotherapy for treatment of cocaine use disorder. [Read the Full Post]