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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Calcium Channel

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

59 views | Feb 11 2024

The study elucidates that L-type voltage-gated calcium channels (LTCCs) govern dopamine release in a regionally and sexually divergent manner, influenced by multiple factors associated with either increased vulnerability or protection against Parkinson's disease. [Read the Full Post]

Optimization of anesthetic procedure in crustaceans: Evidence for sedative and analgesic-like effect of MS-222 using a semi-automated device for exposure to noxious stimulus

60 views | Feb 02 2024

This study demonstrates the efficacy of MS-222 as an anesthetic in Gammarus pulex while introducing a novel semi-automated electric shock device for assessing nociceptive responses in aquatic invertebrates, highlighting its potential for standardized research protocols in this field. [Read the Full Post]

Role of ON and OFF Visual Pathways in Rod- and Cone-Driven Flicker Responses

120 views | Jan 28 2024

The study identified distinct neurotransmitter effects on rod and cone-driven flicker responses, emphasizing the involvement of ON and OFF visual pathways, horizontal cells, and the sensitivity of low-frequency flicker in ophthalmic pathophysiological research. [Read the Full Post]

Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations

61 views | Dec 02 2023

The study demonstrates that the aqueous ethanol extract of Cuminum cyminum attenuates cyclophosphamide-induced bladder toxicity in rats by reducing oxidative stress, inflammation, and smooth muscle overactivity, while in silico analysis identifies potential bioactive compounds for future drug development. [Read the Full Post]

Revisiting matrix hydrogel composed of gelatin and hyaluronic acid and its application in cartilage regeneration

81 views | Nov 25 2023

The biomacromolecule-based bioadhesive matrix hydrogel, composed of methacrylate gelatin and modified hyaluronic acid, demonstrates promising potential for cartilage repair by promoting tissue integration, supporting chondrogenesis of stem cells, and enhancing articular cartilage regeneration in knee osteoarthritis. [Read the Full Post]

Design, synthesis and anti-Chikungunya virus activity of lomerizine derivatives

60 views | Nov 01 2023

The study demonstrated that Lomerizine (Lom) and its derivatives exhibited potent anti-CHIKV activity and low cytotoxicity, particularly compounds B1 and B7, suggesting their potential as effective anti-Chikungunya drugs. [Read the Full Post]

Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function

74 views | Jul 06 2023

This study showed that formulating S-(-)-Bay K8644 (BayK) within lymph-draining nanoparticles (NPs) improved lymphatic vessel function and effectively treated lymphatic dysfunction, providing a promising therapeutic approach. [Read the Full Post]

Regulation of neuropathic pain by microglial Orai1 channels

100 views | May 14 2023

The study found that Orai1 channels are key regulators of microglial reactivity in neuropathic pain, with sex-specific effects observed in female mice. [Read the Full Post]

Concentration dependence of active potassium transport in the human red blood cell in the presence of inhibitors

183 views | Mar 09 2023

The passage describes the inhibition of active potassium influx in human red blood cells by several compounds, including strophanthidin, ethacrynic acid, and MK-870, and suggests a model for the behavior of the transport system in the presence of these compounds and potassium ions. [Read the Full Post]

Metabolic characterization and GAPDH dependent regulation of ENaC in hPheo1 wild-type and SDHB knockdown cells

124 views | Mar 08 2023

The study investigates the expression and activity of ENaC and ASIC ion channels in hPheo1 WT and SDHB KD cells, which may provide important insights into understanding and treating SDHB-related disease. [Read the Full Post]